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Table of Contents
doi : 10.1016/S0015-0282(24)02013-2
Volume 122, Issue 4, Supplement, October 2024, Page i
These abstracts of research studies, published as submitted by the authors, are presented in the ASRM 2024 Congress sessions are published in the order of their presentation. Abstracts of plenary lectures, symposia and interactive sessions are not included. The abstracts presented have been selected based on peer reviewer scores, but have not been subject to the rigors of a peer review process characteristic of scientific publications; thus, the findings should be considered preliminary and are not appropriate for the direction of clinical care. The conclusions expressed in these abstracts are those of the authors and do not necessarily reflect recommendations of the ASRM
OVARIFY: UTILIZING A MACHINE LEARNING MODEL AND CLINICAL FEATURES TO PREDICT POLYCYSTIC OVARY SYNDROME
Adam T. Evans M.D. 1, Eeshaan Rehani B.S. 2, Bailey Smith M.S. 3, Melody Damei Hong B.A. 3, Zoe Lewin B.A. 1, Karina Hiroshige M.B.A., B.S. 1, Iman Hajirasouliha Ph.D. 4, Marla E. Lujan M.Sc., Ph.D. 3, Kathleen Hoeger M.D., M.P.H 1
doi : 10.1016/j.fertnstert.2024.07.071Get rights and content
Volume 122, Issue 4, Supplement, October 2024, Page e1
Polycystic ovary syndrome (PCOS) is the most common reproductive endocrinopathy affecting females worldwide, with a high percentage of cases going undiagnosed. Subjectivity associated with the evaluation of PCOS features contributes to under- and misdiagnoses. Standardization of the assessment of polycystic ovarian morphology (PCOM) could obviate inter-rater variability across clinical settings and streamline the diagnostic evaluation for PCOS. The objective of this study was to evaluate prediction models for PCOS status that integrate machine learning-derived measures of ovarian morphology with anti-mullerian hormone (AMH) levels and other clinical features.
LONG-TERM FOLLOW-UP OF OOCYTE DONORS: THOUGHTS AND FEELINGS ABOUT DONATION AND FUTURE CONTACT WITH CHILDREN FROM THE DONATION
Sarah R. Holley PH.D. 1, Jerrine R. Morris B.S., M.D., M.P.H 2, Eleni Jaswa MD, MSc, MAS 3, Isabelle P. Ryan B.S., M.D. 4, Lihan Kao BA 3, Kelly Forsberg BA 5, Daragh Castaneda B.A. 6, Peggy J. Orlin M.S. 7, Heather Gibson Huddleston M.D. 1, Marcelle I. Cedars MD 1, Lauri Pasch PhD 3
doi : 10.1016/j.fertnstert.2024.07.072Get rights and content
Volume 122, Issue 4, Supplement, October 2024, Page e1
Fertility treatment with donor oocytes is an increasingly utilized family-building option. Little is known, however, about the long-term feelings and views of oocyte donors. This study sought to characterize oocyte donors’: 1) feelings about having been a donor; 2) concerns about the impact of donating on their health; and 3) curiosity, interest in, and willingness for future contact with the children from their donation.
ROLE OF TENASCIN C IN LESION FORMATION INÂ EARLY PERITONEAL ENDOMETRIOSIS
Maako Moriyama M.D., PH.D. 1, Fuminori Taniguchi M.D., PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.073
Volume 122, Issue 4, Supplement, October 2024, Pages e1-e2
We aimed to identify cytokines or extracellular matrix (ECM) components that contribute to adhesion to, and invasion of, the peritoneum, proximal to lesions in the early phase of endometriosis
ESTABLISHMENT OF IN VITRO IMPLANTATION MODEL USING NEWLY DEVELOPED ENDOMETRIAL ORGANOID
Isao Tamura M.D., PH.D., Tetsuro Tamehisa M.D., Norihiro Sugino M.D., PH.D.
doi : 10.1016/j.fertnstert.2024.07.074
Volume 122, Issue 4, Supplement, October 2024, Page e2
Implantation is the process by which a blastocyst attaches to the uterine epithelium and invades the underlying uterine stroma. However, the detailed mechanisms of implantation have not been fully clarified due to the lack of techniques for constructing an organized endometrium-like structure in vitro, which enables to recapitulating the implantation process in vitro. Although endometrial organoids were recently established, they only consisted of endometrial epithelial cells without endometrial stromal cells. In addition, it is important to note that the apical surface of the epithelium of endometrial organoids faces inward (apical-in organoid), which makes it impossible for the blastocyst to attach to the apical surface of the epithelium. Therefore, it is necessary to generate a 3D structure that includes both epithelial and stromal cells and reverse the polarity of the epithelial cells (apical-out organoid). We developed an apical-out endometrial organoid including endometrial epithelial and stromal cells. Additionally, we examined its potential to recapitulate the implantation process when co-cultured with a mouse blastocyst.
AN INTEGRATED PREIMPLANTATION GENETIC TEST COMBINING PRIMARY TEMPLATE DIRECTED AMPLIFICATION, COPY NUMBER VARIATION AND ALLELE FREQUENCY DATA TO GENERATE THE MOST COMPLETE VIEW OF MOSAIC EMBRYOS
Christopher Weier PH.D. 1, Kedrick McKissock BS 2, Alexander Griffith B.S. 3, Kate Brown Ph.D 1
doi : 10.1016/j.fertnstert.2024.07.075
Volume 122, Issue 4, Supplement, October 2024, Page e2
Mosaic embryos, which are estimated to make up 2-25% of PGT-A outcomes, create a challenging clinical decision-point. Most PGT-A platforms are restricted by their methods and are forced to resolve mosaicism with either CNV or SNV data, compromising accuracy, resolution, and confidence. A more comprehensive classification method could provide clarity and aid in selecting the most appropriate embryos for transfer. This study aims to assess the performance of a PGT-A platform leveraging genome wide copy number data and deep SNP-based allelic frequency data from a single embryo to best characterize mosaic copy number variation.
A NOVEL TIME-LAPSE 3D IN VITRO CO-CULTURE SYSTEM TO CHARACTERIZE EXTRACELLULAR COMMUNICATION ASSOCIATED WITH IMPLANTATION SUCCESS
Keelee J. McCarty PhD 1, Blair R. McCallie PH.D. 1, William B. Schoolcraft MD 2, Mandy Katz-Jaffe PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.076
Volume 122, Issue 4, Supplement, October 2024, Pages e2-e3
Implantation failure is a leading contributor to human infertility. Implantation relies on temporal and spatial gene expression from the receptive maternal endometrium communicating with a developmentally competent preimplantation embryo. Due to ethical and mechanistic constraints, evaluation of the intricate bi-directional molecular signaling required to establish embryonic apposition, adhesion, and invasion, has proven challenging. The objective of this study was to utilize a novel, time-lapse 3D in vitro co-culture system to characterize extracellular molecular communication during the window of implantation (WOI).
TRAJECTORIES IN ANTIMULLERIAN HORMONE (AMH) DECLINE ACROSS THE MENOPAUSE TRANSITION; STUDY OF WOMEN’S HEALTH ACROSS THE NATION (SWAN)
Laura Bozzuto M.D., M.S. 1, Kelly S. Acharya M.D. 2, Laura Katherine Kaizer MPH 3, Joel Finkelstein MD 4, Arun Karlamangla MD 5, Genevieve S. Neal-Perry M.D., Ph.D. 6, Anthony Morrison B.Sc., MBA 7, Nanette Santoro M.D. 8, Mary D. Sammel ScD 9
doi : 10.1016/j.fertnstert.2024.07.079
Volume 122, Issue 4, Supplement, October 2024, Page e4
Declining antimullerian hormone (AMH) levels can predict the timing of the final menstrual period (FMP); however, a wide range in AMH has been seen across the menopause transition. This study sought to perform a trajectory analysis of AMH decline leading to the FMP to determine if distinct patterns of AMH decline exist and if these are associated with participant characteristics.
NOVEL CHARACTERISATION TOOLS FOR HUMAN PLOIDY ABNORMALITIES REVEALS A LINK TO MEIOTIC RECOMBINATION AND THE IDENTIFICATION OF A PREVIOUSLY UNDESCRIBED PHENOMENON
Ludovica Picchetta MSc 1, Christian S. Ottolini BSc, PhD 1, Francesca Mulas PhD 1, Federico Bianca MSc 1, Xin Tao H.C.L.D, PH.D. 2, Yiping Zhan Ph.D 3, Maria Jose Escribà Pérez PhD 4, Emily Mounts M.S. 3, Christine V. Whitehead MS, B.S.N., R.N. 5, Thomas Molinaro MD, MSCE 6, Chaim Jalas N/A 7, Antonio Capalbo PhD 1
doi : 10.1016/j.fertnstert.2024.07.080
Volume 122, Issue 4, Supplement, October 2024, Pages e4-e5
Development and validation of bespoke algorithms and analytical tools to characterize incidence, origin, and potential causative mechanisms of ploidy abnormalities in human preimplantation embryos.
EMBRYONIC DE NOVO COPY NUMBER VARIANTS IDENTIFIED IN EUPLOID PREGNANCY LOSSES
Charles Wageman BS, Whitley R. Lehto PhD, Mary E. Haywood PhD, Rachel Lee M.S., Lauren Henry B.S., Mandy Katz-Jaffe PH.D.
doi : 10.1016/j.fertnstert.2024.07.081
Volume 122, Issue 4, Supplement, October 2024, Page e5
Though infrequent, pregnancy loss following the transfer of a euploid blastocyst does occur. Current next-generation sequencing (NGS) platforms for preimplantation genetic testing (PGT) typically quote >5-10MB resolution to identify chromosome abnormalities. Microdeletion and microduplication syndromes (MMS), which are pathogenic due to haploinsufficiency of a few critical genes, typically range from 1-3MB long and are often undetected by current NGS PGT platforms. The aim of this study was to examine surplus trophectoderm (TE) biopsy DNA of euploid pregnancy losses for copy number variants (CNVs) and pathogenic genetic causes for fetal demise.
DO GUIDELINES MATTER? A COMPARISON OF MULTIPLE BIRTH RATES BEFORE AND AFTER THE PUBLICATION OF THE 2017 ASRM/SART EMBRYO TRANSFER GUIDELINE
Katie M. Baker M.D. 1, Emily Zitek BA 2, Jennifer L. Eaton M.D., M.S., M.SC. 1
doi : 10.1016/j.fertnstert.2024.07.082
Volume 122, Issue 4, Supplement, October 2024, Page e5
In 2017, the American Society for Reproductive Medicine (ASRM) and the Society for Assisted Reproductive Technology (SART) released updated guidelines regarding limits on the number of embryos to transfer with the goal of reducing the multiple birth rate (MBR). These revised guidelines strongly recommended single embryo transfer (SET) for favorable prognosis patients under the age of 38 years and for all patients undergoing transfer of a euploid embryo. The impact of this revision on national ET practice patterns and MBRs has not been formally studied
COST-EFFECTIVENESS ANALYSIS OF PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) IN GOOD PROGNOSIS PATIENTS
Ariel J. Dunn MD 1, Kerry S.J. Flannagan PhD 2, Kiley Hunkler M.D., MSt, MSc 3, Micah J. Hill DO 4, Phillip A. Romanski M.D., M.SC. 5, Saioa Torrealday MD 1, Chinormso Diribe MD 6, Terrence D. Lewis M.D., PH.D. 1, Alan DeCherney MD 7, Kathleen Devine MD 8, Michael Levy M.D. 9, Joshua C. Combs B.S., M.D. 10
doi : 10.1016/j.fertnstert.2024.07.083
Volume 122, Issue 4, Supplement, October 2024, Pages e5-e6
Preimplantation genetic testing for aneuploidy (PGT-A) putatively improves embryo selection, decreases risk for miscarriage and potentially time in treatment, but increases costs of an IVF cycle1,2. Prior studies found PGT-A is cost-effective in patients of advanced age, but not cost-effective for patients using donor oocytes3. Less is known about the cost-effectiveness of PGT-A in patients using autologous oocytes who are at low risk of aneuploidy. Our objective was to determine cost-effectiveness of PGT-A for a single frozen embryo transfer (FET) in patients at low risk of aneuploidy (age 26-34 years old) using autologous oocytes compared to transferring untested embryos.
ECONOMIC BENEFIT OF AN EPIGENETIC MALE INFERTILITY ASSESSMENT
Dr. Kristin Brogaard PhD, Lorry Schneider B.S., Andy Olson B.S., M.B.A.
doi : 10.1016/j.fertnstert.2024.07.085
Volume 122, Issue 4, Supplement, October 2024, Pages e6-e7
Male infertility affects 70 million men worldwide. The gold standard male infertility diagnostic is the semen analysis, which visually monitors the sperm quantity, shape, and movement under a microscope. Unfortunately, semen analyses fail to identify a significant number of sub-fertile men. Consequently, when sub-fertile men go undiagnosed, the female partners are often subjected to unsuccessful treatments and procedures. The Sperm Quality Test (SpermQT) is a novel epigenetic analysis that improves the assessment of sperm functionality and fertility potential. The results of SpermQT can help physicians recommend effective, individualized treatments for infertility. The economic impact of SpermQT to patients, fertility clinics, and fertility benefit payers has been assessed utilizing large national and retrospectively collected data
FERTILITY PRESERVATION AND INFERTILITY TREATMENT IN FEMALE SURGICAL TRAINEES IN ALBERTA: A SURVEY OF TRAINEE KNOWLEDGE, ATTITUDES, AND NEEDS
Sylvie Bowden BScN, MD, Amy Metcalfe PhD, Shu Foong MD, FRCSC
doi : 10.1016/j.fertnstert.2024.07.086
Volume 122, Issue 4, Supplement, October 2024, Page e7
We aimed to describe fertility knowledge and views on family planning, oocyte cryopreservation (OC), and fertility treatment among female surgical residents and fellows in Alberta.
REPRODUCTIVE ENDOCRINOLOGIST PERSPECTIVES ON PHYSICIAN PREGNANCY (REPPP)
Rachel M. Whynott M.D. 1, Karen M. Summers MPH CHES 2, Emily A. Capper M.D. 3, Stacey A. Pawlak PH.D. 4
doi : 10.1016/j.fertnstert.2024.07.087
Volume 122, Issue 4, Supplement, October 2024, Page e7
To determine the impact of being pregnant while working as a reproductive endocrinology and infertility (REI) subspecialist.
DO REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY FELLOWSHIP WEBSITES REFLECT A COMMITMENT TO DIVERSITY, EQUITY, AND INCLUSION?
Jasmine Eliwa M.D. 1, Patricia J. Goedecke MS 2, Jim Y. Wan Ph.D. 2, Rachel Susan Weinerman M.D. 3, Joseph Findley M.D. 3, Kathryn D. Coyne M.D. 3, Sung Tae Kim PhD, HCLD 3, Rebecca Flyckt M.D. 3
doi : 10.1016/j.fertnstert.2024.07.088
Volume 122, Issue 4, Supplement, October 2024, Page e8
The American Society for Reproductive Medicine (ASRM) Diversity, Equity, and Inclusion (DEI) Taskforce identified a lack of diversity in fellowship trainees and a gap in data regarding diversity in reproductive care providers. Fellowship websites are a method for recruiting underrepresented in medicine applicants, especially in an era of virtual interviews. This study aims to characterize the frequency of diversity elements described in reproductive endocrinology and infertility (REI) fellowship websites and hypothesizes that diversity elements may vary according to geographic region
MATCHING DURING A CRISIS: RECRUITMENT OF REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY FELLOWS OUTSIDE OF THE FORMAL MATCH PROCESS DURING THE COVID-19 PANDEMIC
Emilie M. Stylli MD 1, Caitlin E. Martin MD, MS 1, Christopher X. Hong MD 2, Divya K. Shah MD, MME 1, Leigh A. Humphries MD 1
doi : 10.1016/j.fertnstert.2024.07.089
Volume 122, Issue 4, Supplement, October 2024, Page e8
By accepting candidates “outside of the Match,” fellowship programs can bypass the typical application, interview, and ranking process through the National Resident Matching Program (NRMP). The COVID-19 pandemic disrupted fellowship recruitment in 2020, requiring a transition to virtual interviews and limiting networking with applicants, and this may have influenced participation in the Match process. This study investigated changes in the proportions of REI fellows who were accepted outside of the NRMP Match before and after the pandemic, as well as the proportion of fellows recruited from their home institutions
CAREER OUTCOMES OF OBSTETRICS AND GYNECOLOGY RESIDENTS WHO COMPLETE AN AWAY ELECTIVE IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY
Rei Yamada MD 1, Cecilia Rosenbaum MD 2, Selena U. Park MD 3, Howard J. Li MD 3, Alan DeCherney MD 3
doi : 10.1016/j.fertnstert.2024.07.090
Volume 122, Issue 4, Supplement, October 2024, Pages e8-e9
Our institution has the largest reproductive endocrinology and infertility (REI) fellowship in the country and has been offering a unique clinical elective to visiting residents since 2012. The aim of this study was to examine career outcomes of obstetrics and gynecology (OB/GYN) residents who participate in the REI elective at our institution.
OUTCOMES FROM IVF CYCLES USING PREIMPLANTATION TESTING FOR ANEUPLOIDY (PGT-A) IN LEAN VS. OVERWEIGHT PATIENTS WITH POLYCYSTIC OVARY SYNDROME (PCOS)
Mitko Madjunkov M.D. 1, Rina Abramov MSc 1, Svetlana Madjunkova M.D., M.SC., PH.D. 2, Clifford Librach MD 1
doi : 10.1016/j.fertnstert.2024.07.091
Volume 122, Issue 4, Supplement, October 2024, Page e9
Polycystic Ovary Syndrome (PCOS) is the most common hormonal disorder leading to anovulatory infertility. The objective of our study was to evaluate embryo (EMB)ploidy rate among an infertile population with PCOS compared to non-PCOS controls, and to compare the outcomes between lean and obese PCOS patients and matched controls.
THE ROLE OF PGT-A ON SIBLING EMBRYOS GENERATED FROM OOCYTES OF DIFFERENT AGES
Olena M. Kocur B.A., Philip Xie B.SC., Zev Rosenwaks M.D., Gianpiero D. Palermo M.D., PH.D.
doi : 10.1016/j.fertnstert.2024.07.092
Volume 122, Issue 4, Supplement, October 2024, Pages e9-e10
Advanced maternal age increases the risk of oocyte chromosomal abnormalities. Oocyte cryopreservation at a younger age has become a common practice to preserve healthy gametes.
PERFORMANCE OF TWO PGT PLATFORMS UTILIZED WITHIN A SINGLE ASSISTED REPRODUCTIVE CENTER
Diana Garro BS 1, Aleska Valadez B.S. 2, Dante J. Sanchez B.Sc 3
doi : 10.1016/j.fertnstert.2024.07.093
Volume 122, Issue 4, Supplement, October 2024, Page e10
The differences between next-generation sequencing (NGS)-based PGT and single nucleotide polymorphism (SNP) array PGT laboratories extend beyond technology, encompassing variations in protocols, validations, and accreditations. These elements likely influence the variations in reported ploidy rates by each laboratory. Furthermore, since aneuploidies account for the majority of implantation failures, their analysis can be used to infer rates of false positive diagnoses. Therefore, this study compares the performance of NGS-based and SNP array-based PGT platforms with regard to both aneuploidy frequencies and biochemical pregnancy rates.
EVALUATION OF NO-CALL ETIOLOGIES IN PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A): INFLUENCE ON GENETIC AND CLINICAL OUTCOMES FOLLOWING REBIOPSY
Francesca Barrett M.B.A., M.D. 1, Emily Mounts M.S. 2, Benjamin Forman BA 2, Yiping Zhan Ph.D 2, Blake Vessa M.D. 3, Xin Tao H.C.L.D, PH.D. 2, Chaim Jalas N/A 4
doi : 10.1016/j.fertnstert.2024.07.094
Volume 122, Issue 4, Supplement, October 2024, Page e10
To evaluate trophectoderm (TE) blastocyst inconclusive PGT-A result rates and etiologies; assess aneuploidy rates on rebiopsy samples vs initial biopsies; and describe clinical outcomes of transferred embryos that were negative for aneuploidy after rebiopsy.
EFFECT OF TROPHECTODERM REBIOPSY ON SERUM Î’-HUMAN CHORIONIC GONADOTROPIN LEVELS IN PREGNANCIES RESULTING IN LIVE BIRTHS
Rebecca Zhuo M.D. 1, Tamar Alkon-Meadows M.D. 2, Samantha Lauren Estevez M.D. 1, Atoosa Ghofranian M.D. 1, Emily Auran Clarke M.D. 1, Morgan Baird MPH 2, Joseph A. Lee BA 2, Dmitry Gounko B.S., M.A. 2, Rachel B. Danis M.D. M.S 2, Alan B. Copperman M.D. 3, Erkan Buyuk M.D. 3
doi : 10.1016/j.fertnstert.2024.07.095
Volume 122, Issue 4, Supplement, October 2024, Pages e10-e11
Approximately 5 to 7 cells are removed from the trophectoderm (TE) during embryo biopsy for preimplantation genetic testing for aneuploidy (PGT-A). Rebiopsy is performed in 1-3% of cases due to inconclusive results. The TE gives rise to the placenta which produces ? human chorionic gonadotropin (?-hCG), an important diagnostic and prognostic marker in early pregnancy (1). Whether rebiopsy depletes TE cell count to a degree that could affect ?-hCG levels is yet to be established. This study aimed to assess if rebiopsy is associated with lower ?-hCG in early pregnancy compared to once-biopsied or untested embryos.
MULTI-GENERATIONAL BLINDING OF PRE-IMPLANTATION GENETIC TESTING RESULTS FOR HUNTINGTON’S DISEASE: A CASE REPORT
Samuel R. Raine M.D. 1, Dana R. Siegel M.D. 2, Hannah Elfman MS, CGC 2, Liya Rabkina MS, CGC 3, Paulina Nassab MS, CGC 4, Alex J. Polotsky M.D., M.S. 2
doi : 10.1016/j.fertnstert.2024.07.096
Volume 122, Issue 4, Supplement, October 2024, Page e11
This case highlights the unique workflow of non-disclosure pre-implantation genetic testing for monogenic diseases (PGT-M) in a couple with unknown Huntington’s Disease (HD) carrier status (CS) across multiple generations.
DEFINING SEGMENTAL ANEUPLOIDY LIMITS OF DETECTION WITH PGT
Heather Garnsey B.S., M.P.S, Diego Marin PH.D., Jia Xu PhD, Nathan R. Treff PhD, HCLD
doi : 10.1016/j.fertnstert.2024.07.097
Volume 122, Issue 4, Supplement, October 2024, Pages e11-e12
In order to properly diagnose segmental aneuploidy (SA) in embryo biopsy samples, limits of detection (LOD) should be established. This study used samples submitted for preimplantation genetic testing for structural rearrangements (PGT-SR) to re-evaluate the SA LOD with a high-resolution PGT platform.
A SINGLE BASE RESOLUTION PGT-SR TEST USING WHOLE GENOME APPROACH
Nabil Arrach Ph.D. 1, Hyunsoo Kim PhD 2, Lena Barbakh B.S., B.A. 3, Santiago Munne PhD 4
doi : 10.1016/j.fertnstert.2024.07.098
Volume 122, Issue 4, Supplement, October 2024, Page e12
This current high-resolution translocation test is designed to identify embryos with balanced translocations from normal embryos and remove the size limitation of unbalanced translocation detection with conventional PGT-SR platforms.
ASSESSING THE REPRODUCTIVE POTENTIAL OF LATE MATURE OOCYTES IN EGG FREEZING CYCLES
Keri Bergin B.S., M.D. 1, Richard E. Slifkin M.S. 2, Carlos Hernandez-Nieto MD 2, Morgan Baird MPH 2, Dmitry Gounko B.S., M.A. 2, Joseph A. Lee BA 2, Chelsea M. Canon MD 2, Lucky Sekhon M.D. 2, Alan B. Copperman M.D. 2
doi : 10.1016/j.fertnstert.2024.07.099
Volume 122, Issue 4, Supplement, October 2024, Page e12
Following vaginal oocyte retrieval (VOR), oocytes are assessed for germinal vesicle (GV) meiosis I (MI), or meiosis II (MII) development prior to cryopreservation. Given evidence of improved maturation rates of immature oocytes prior to cryopreservation rather than post thaw (1), GV and MI oocytes may be cultured in the laboratory to reassess maturation before cryopreservation. It is not established whether oocytes with delayed maturation have reduced reproductive potential. The objective of this study is to assess clinical outcomes in oocytes that reached the MII stage of development either on first assessment after VOR or later the same day.
PRIOR TESTOSTERONE USE DOES NOT APPEAR TO IMPACT OOCYTE CRYOPRESERVATION OUTCOMES IN TRANSGENDER PATIENTS: FINDINGS FROM A MULTICENTER HEALTH MAINTENANCE ORGANIZATION
Natasha Raj-Derouin MD, MS 1, Snunit Ben-Ozer M.D. 2, Amy S. Dhesi M.D. 3, Tracy NH. Harrison M.D., M.S. 4, Manda Ghahremani M.D. 5, Sami I. Jabara M.D. 3, Marsha B. Baker M.D., M.P.H 2
doi : 10.1016/j.fertnstert.2024.07.100
Volume 122, Issue 4, Supplement, October 2024, Pages e12-e13
Fertility preservation (FP) is becoming more commonly offered and utilized by the transgender community. However, limited research exists regarding the effect of gender-affirming hormonal therapy such as testosterone (T) on oocyte cryopreservation outcomes. The objective of this study is to compare the outcomes of oocyte cryopreservation in transgender patients with and without prior T use.
EVALUATING THE EFFECTS OF INTRAOVARIAN PLATELET-RICH PLASMA (PRP) ADMINISTRATION ON OVARIAN RESPONSE IN PATIENTS WITH DIMINISHED OVARIAN RESERVE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Shorha Qaderi MD 1, Nikan Zargarzadeh MD 2, Ali Javinani MD 3, Giulia Bonanni MD 4, Alexander M. Quaas M.D., PH.D. 5, Alan S. Penzias M.D. 6, Sara Elizabeth Arian M.D., MSc 7
doi : 10.1016/j.fertnstert.2024.07.101
Volume 122, Issue 4, Supplement, October 2024, Page e13
To evaluate the impact of intraovarian PRP administration on ovarian reserve and pregnancy outcomes in patients with diminished ovarian reserve (DOR)
RISK OF SERIOUS ADVERSE EVENT AFTER FERTILITY PRESERVATION PROCEDURES: A COMPARISON OF CANCER AND NON-CANCER PATIENTS
Michael Grynberg M.D., Ph.D. 1, Christophe Sifer PharmD 2
doi : 10.1016/j.fertnstert.2024.07.102
Volume 122, Issue 4, Supplement, October 2024, Pages e13-e14
To analyze whether cancer patients have a higher risk of serious adverse event associated to fertility preservation (FP) procedures compared to non-cancer patients.
A SERIES OF FOUR OVARY ALLOTRANSPLANTS REQUIRING IMMUNOSUPPRESSION
Sherman Silber M.D. 1, Sierra Goldsmith M.S. 1, Anibal G. Melo MD 2, Rowena Delos Delos Santos MD 3, Daniel C. Brennan MD 4
doi : 10.1016/j.fertnstert.2024.07.103
Volume 122, Issue 4, Supplement, October 2024, Page e14
Young women with Turners or POI have been unable to have children without the use of donor egg IVF, but many of these women would like to have normal hormonal function and be able to become pregnant naturally. Previously frozen ovarian cortex tissue can be successfully auto-transplanted back to such women (as well as ovary tissue from an identical twin sister) resulting in normal pregnancy and live births. However this has never been accomplished from a non-identical donor to her sister or cousin because it would require immunosuppression. This would vastly increase the availability and use of ovary transplantation.
ATTITUDES REGARDING ELECTIVE CRYOPRESERVATION AMONG MEDICAL TRAINEES
Rachel Nelson M.D., M.S., PH.D. 1, Natalie Vukmer D.O., M.S. 2, Ringland S. Murray Jr. B.A., M.D. 2, Jessica G. Scotchie M.D. 2
doi : 10.1016/j.fertnstert.2024.07.104
Volume 122, Issue 4, Supplement, October 2024, Page e14
This study aims to assess knowledge and attitudes regarding fertility-related care and to help identify possible barriers to care, emphasizing the concept of elective oocyte cryopreservation amongst medical trainees
OOCYTE CRYOPRESERVATION OUTCOMES IN PATIENTS WITH SEVERE BENIGN HEMATOLOGIC DISEASES PRIOR TO CURATIVE TREATMENT
Andrew J. Claffey MD 1, Sarah Capelouto Cromack MD 2, Kristin N. Smith B.S. 2, Mary Ellen Pavone MD, MSc 2, Kara N. Goldman M.D. 2, Jessica R. Walter MD, MSCE 2
doi : 10.1016/j.fertnstert.2024.07.105
Volume 122, Issue 4, Supplement, October 2024, Pages e14-e15
To describe fertility preservation outcomes in patients with severe benign hematologic diseases requiring curative stem cell transplant or gene therapy.
DEMOGRAPHIC FACTORS PREDICT OOCYTE UTILIZATION WHILE CLINICAL METRICS DETERMINE OUTCOMES FOR PATIENTS UNDERGOING PLANNED FERTILITY PRESERVATION
Rachael Dauria M.D., B.S. 1, Amanda D. Kadesh M.D., M.S. 1, Jordan Naylor MD, MS, MSc, MBA 1, Jeffrey Thorne M.D., M.S., M.A. 2, Karen Wheeler B.S., M.D. 2
doi : 10.1016/j.fertnstert.2024.07.106
Volume 122, Issue 4, Supplement, October 2024, Page e15
Increased awareness of age-related fertility decline combined with improvements in oocyte cryopreservation has dramatically increased the number of patients undergoing planned fertility preservation. The majority of patients never return to use their oocytes, and it is unclear which population of patients benefits from oocyte cryopreservation. The goal of this project is to better characterize the clinical population who utilize their frozen oocytes and have successful pregnancies.
RE-EXPANSION CAPABILITY OF EUPLOID BLASTOCYSTS AFTER WARMING IS PREDICTIVE OF PREGNANCY OUTCOME, BUT NOT THE EXPANSION DEGREE AT THE TIME OF BIOPSY
Takumi Takeuchi M.D., PH.D. 1, Shimpei Mizuta M.HS. 2, Masakazu Doshida MD, PhD 1, Aya Karino M.D. 1, Yurino Ishibashi M.D. 1, Saki Saito M.D. 1, Yukiko Takaya MD 2, Kohei Yamaguchi M.D., Ph.D. 2, Yasuhiro Ohara M.D. 2, Hidehiko Matsubayashi M.D., PH.D. 2, Tomomoto Ishikawa M.D., PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.107
Volume 122, Issue 4, Supplement, October 2024, Pages e15-e16
The developmental competence of euploid embryos has been reported consistent regardless of the morphology at the time of biopsy in preimplantation genetic testing for aneuploidy (PGT-A). However, the predictive value of the blastocyst morphology, particularly the impact of re-expansion of vitrified euploid blastocysts after warming on the implantation potential has yet to be elucidated. To assess the impact of euploid blastocyst re-expansion on pregnancy outcomes, rates of clinical pregnancy (CP), miscarriage, and ongoing pregnancy (OP) or live birth (LB) were compared according to the degree of blastocoel re-expansion after warming immediately before embryo transfer.
COMPARISON OF ONE-STEP AND MULTI-STEP WARMING PROTOCOLS: A SERIES OF 1689 BLASTOCYTS
Hakan Kadir Yelke MsC 1, Yesim Kumtepe Colakoglu M.Sc 1, Tutku Melis Aygün M.Sc 1, Caroline Pirkevi Cetinkaya PhD 1, Semra Kahraman Prof. MD 2
doi : 10.1016/j.fertnstert.2024.07.108
Volume 122, Issue 4, Supplement, October 2024, Page e16
Vitrification has played a key role in cryopreserving human embryos successfully and has expanded the therapeutic options for couples requiring fertility treatment. However, there remains an opportunity and necessity to continue to improve and shorten protocols to facilitate the laboratory workflow. The aim of the present study was to determine whether embryos warmed using a one-step rehydration protocol leads to comparable pregnancy and live birth outcomes when compared to conventional protocols
ONE-STEP WARMING: OPTIMIZES WORKFLOW AND EFFICIENCY IN THE IVF LABORATORY WITHOUT COMPROMISING OUTCOMES
Rian S. Chrobocinski PhD 1, Dora M. Chan BA 2, Nathan C. Koelper MPH 2, Robin Skory M.D., PH.D. 2, Clarisa R. Gracia MD, MSCE 2, Dara S. Berger M.P.H, PH.D. 3
doi : 10.1016/j.fertnstert.2024.07.109
Volume 122, Issue 4, Supplement, October 2024, Page e16
To compare pregnancy rates (PR) and clinical pregnancy rates (CPR) between embryos warmed using one-step warming and standard multi-step warming protocols.
IMPROVEMENT OF EPIGENETIC MODIFICATION AND DEVELOPMENTAL RATE BY SCRIPTAID IN ROSI
Atsushi Tanaka M.D., PH.D. 1, Motoi Nagayoshi M.D. 1, Daisuke Nakajima M.D. 1, Yuya Makino M.D. 1, Idumi Tanaka Phar.B. 1, Seiji Watanabe Ph.D. 2, Masahiko Ito Ph.D. 3
doi : 10.1016/j.fertnstert.2024.07.110
Volume 122, Issue 4, Supplement, October 2024, Pages e16-e17
The development and birth rates of mouse ROSI embryos (40%, 21%) are lower compared to those of ICSI embryos (74%, 45%), possibly due to global methylation of histone H3K9 in the male pronucleus from microinjected round spermatids. Histone methylation is typically inhibited by histone deacetylase inhibitors. Mouse ROSI embryos treated with Scriptaid (250nM) for 10h show reduced methylation of histone H3K9, leading to improved development and birth rates similar to those of ICSI (59%, 40%). Through the use of Scriptaid, this study aims to explore the importance of histone modifications in human ROSI embryos for development, risks, and safety. This study has been approved by the Institutional Review Board.
CAN IMMATURE OOCYTES ‘CATCH-UP’? EMBRYO DEVELOPMENT AND REPRODUCTIVE POTENTIAL OF LATE-MATURED CRYOPRESERVED OOCYTES
Keri Bergin B.S., M.D. 1, Morgan Baird MPH 2, Dmitry Gounko B.S., M.A. 2, Carlos Hernandez-Nieto MD 2, Richard E. Slifkin M.S. 2, Joseph A. Lee BA 2, Devora Aharon M.D. 2, Eric Flisser M.D. 2, Alan B. Copperman M.D. 2, Lucky Sekhon M.D. 2
doi : 10.1016/j.fertnstert.2024.07.111
Volume 122, Issue 4, Supplement, October 2024, Page e17
Oocytes that reach the metaphase II (MII) stage of development are cryopreserved for fertility preservation. Oocytes initially noted to be at the germinal vesicle (GV) or meiosis I (MI) stage following vaginal oocyte retrieval (VOR) often mature in vitro to the MII stage. While these late mature MII oocytes can be cryopreserved, there is a lack of data on their reproductive potential when thawed for future use. This study assesses the embryo quality and pregnancy outcomes after thaw and fertilization of late mature oocytes compared to oocytes that were mature at first assessment.
LABORATORY OUTCOMES AFTER ULTRA-RAPID WARMING OF HUMAN CRYOPRESERVED CLEAVAGE-STAGE EMBRYOS
Nagham Younis PH.D. 1, Ahmad Morsi Abu Maizar B.SC., M.SC. 2, Yekaterina Rousakova B.Sc. 3, Katie Hulst M.Sc. 3, Melissa Johnson B.SC. 4, Aletta Dorothea Esterhuizen PH.D., HCLD, TS, CC 5, Matthew VerMilyea H.C.L.D, PH.D. 6
doi : 10.1016/j.fertnstert.2024.07.112
Volume 122, Issue 4, Supplement, October 2024, Pages e17-e18
Ultra-rapid warming (URW) of human cryopreserved blastocyst embryos using a one-step protocol has been evaluated and implemented showing a similar survival rate compared to the multi-step standard warming (SW) protocol. However, this novel protocol has not been assessed with cryopreserved cleavage-stage embryos yet. This study aims to evaluate the lab outcomes including survival, viability, and blastocyst formation rate after ultra-rapid warming of cryopreserved cleaved embryos that were originally cryopreserved using slow-freeze or vitrification protocols.
“QUICK AS LIGHTNING”: A FRENCH 12-MONTH EXPERIENCE OF ULTRAFAST BLASTOCYST WARMING ON MORE THAN 1000 SINGLE FROZEN-THAWED BLASTOCYST CYCLES
Thomas Freour Ph.D., PHARM.D. 1, Hubert Joris B.SC. 2, Jenna Lammers PhD 3, Sophie Loubersac MD 4
doi : 10.1016/j.fertnstert.2024.07.113
Volume 122, Issue 4, Supplement, October 2024, Page e18
As vitrification represents a significant and increasing workload in the IVF lab, we evaluated here if an ultrafast blastocyst warming procedure could streamline and improve lab’s workflow while maintaining clinical outcome
PRE-TRANSFER ENDOMETRIAL GROWTH AND BLASTOCYST TROPHECTODERM MEASUREMENT CORRELATE WITH BIRTH WEIGHT AFTER CONTROLLING FOR GESTATIONAL AGE, BODY MASS INDEX, AND INFANT SEX
Carrie E. Bedient M.D., Leah A. Kaye B.A., M.D., M.S., Forest C. Garner M.S., Masumi Padhye MD, Bruce S. Shapiro M.D., Ph.D., H.C.L.D.
doi : 10.1016/j.fertnstert.2024.07.114
Volume 122, Issue 4, Supplement, October 2024, Page e18
The current study investigates whether pre-transfer embryonic and endometrial measurements are associated with birth weight
ALTERED GAP JUNCTION GENE EXPRESSION IN CUMULUS CELLS MAY CONTRIBUTE TO DECREASED OOCYTE QUALITY WITH AGING
Shawn M. Briley Ph.D., Mary E. Haywood PhD, Mandy Katz-Jaffe PH.D
doi : 10.1016/j.fertnstert.2024.07.115
Volume 122, Issue 4, Supplement, October 2024, Pages e18-e19
Communication via gap junctions between granulosa cells and the oocyte are essential for folliculogenesis and producing a high-quality oocyte. Disruption of gap junctions result in impaired oocyte development and meiotic maturation. Recently, it has been shown that transzonal projections (TZP) between granulosa cells and oocytes decrease with maternal aging. Additionally, spatial transcriptomic data has demonstrated that gap junction regulation is aberrantly impacted in the ovaries of aged mice. The aim of this study was to examine the associations between maternal aging and the expression of key genes involved in follicular TZP and gap junction formation and regulation.
MITOQUINOL IMPROVES IONOMYCIN-INDUCED PARTHENOGENETIC EMBRYONIC DEVELOPMENT
Mingxiang Zhang PhD 1, Alex Lagunov MSc, BSc 2, Jason E. Swain PH.D. 3, William B. Schoolcraft M.D. 4, Ye Yuan PH.D. 4
doi : 10.1016/j.fertnstert.2024.07.116
Volume 122, Issue 4, Supplement, October 2024, Page e19
Artificial oocyte activation (AOA) reagents are sometimes used during IVF to assist with fertilization. Other than ionophore A23187, ionomycin and SrCl2 are both novel AOA reagents being investigated. This study compared the efficiency of different AOA agents in conjunction with mitoquinol (MitoQ), a mitochondria-targeted antioxidant, on embryonic development after parthenogenetic activation (PA).
PROLONGED INGESTION OF CRUDE OIL SPILL CONTAMINATED WATER AFFECTS MALE REPRODUCTIVE SYSTEM, HORMONES AND ACCESSORY ORGANS IN PIGS
Louis C.C. Ajonuma MD, PhD 1, David O. Fapohunda BSc 2, Saka A. Bamiro MBBS, PhD 3, Samira Lobo Makanjuola PhD 4, Ikechukwu I. Okoye BSc. 2
doi : 10.1016/j.fertnstert.2024.07.117
Volume 122, Issue 4, Supplement, October 2024, Page
Crude oil spill in the Niger delta region of Nigeria has been on the rise leading to pollution of major drinking water sources. The pollution of these river sources contaminate these sources for drinking, bathing and other domestic purposes. Results from our laboratory revealed that crude oil spill contaminated water affects male reproductive system in rats, however, studies have not been carried out to elucidate its effects on higher animals. This study evaluated the effects of crude oil spill contaminated water on male reproductive system, hormones and accessory organs in pigs.
EFFECTS OF EXPERIMENTAL TESTICULAR HEAT EXPOSURE ON SPERM DNA INTEGRITY AND MITOCHONDRIAL ACTIVITY
Mika Alexia Miyazaki MSC 1, Raquel Guilharducci MSC 1, Joana da Silva Melin Para-Assú BSc 1, Mariana Camargo PhD 2, Ricardo P. Bertolla DVM, PhD, HCLD(ABB) 3
doi : 10.1016/j.fertnstert.2024.07.118
Volume 122, Issue 4, Supplement, October 2024, Pages e19-e20
Occupational exposure to heat has been shown to cause testicular heat stress. In men that work in hot conditions, an increase of 1 oC may cause a decrease in 40% of sperm production, while it has been shown that male welders and bakers present a significantly increased time to pregnancy. National Institute for Occupational Safety and Health (NIOSH) establishes the need to monitor and combat heat-induced damage to human health. In the case of male exposure to heat, removing exposure has been suggested to reverse effects. However, we do not know if alterations to sperm functional quality persist after a full spermatogenic cycle (i.e. if there are persistent damages to spermatogonia). This experimental study aims to simulate a transient testicular hyperthermia event that mimics occupational testicular heat stress, and to verify if alterations persist after a full spermatogenic cycle of recovery.
A COMPARATIVE ANALYSIS OF THE USE OF CRISPR/dCas ENGINEERED MSCs AND EXOSOMES VERSUS NON-ENGINEERED MSCs AND EXOSOMES FOR PREVENTION OF CISPLATIN-INDUCED OVARIAN FAILURE IN MICE
Ariana Sivaslioglu MS 1, Gizem Söyler PhD 2, Ipek Yilmaz MS 3, Mehmet Eren Eren Ciftci BSc 4, Ruya Sera Sera Polat BSc 4, Said Incir MD 5, Sercin Karahuseyinoglu MD 6
doi : 10.1016/j.fertnstert.2024.07.119
Volume 122, Issue 4, Supplement, October 2024, Page e20
This study aims to evaluate the potential effects of using CRISPR/dCas9-engineered Mesenchymal Stem Cells (MSCs) and/or their exosomes as pretreatment to reduce cisplatin-induced ovarian tissue damage in mouse.
HYALURONIC ACID SYSTEM IN RHESUS MONKEYS AS A MODEL FOR STUDYING THE PATHOGENESIS OF EARLY ENDOMETRIOTIC LESIONS
Katherine E. Kostroun MD, Alondra L. Rodriguez Sanchez BA, Rajeshwar Rao Tekmal PhD, Claire M. Schenken MD, Robert S. Schenken M.D.
doi : 10.1016/j.fertnstert.2024.07.120
Volume 122, Issue 4, Supplement, October 2024, Pages e20-e21
To study the effects of 4-methylumbelliferone (4-MU) salt on rhesus monkey endometrial cell viability, expression of the hyaluronic acid system, as well as attachment, migration, and invasion of rhesus monkey endometrial epithelial cells (EECs) and stromal cells (ESCs) to rhesus peritoneal mesothelial cells (PMCs).
SENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE
Jiahui Zhang MD 1, Jesus Lopez BS 2, Jing Liang PhD 3, Meirav Sela Msc 2, Amanda Nicole Kallen M.D. 1
doi : 10.1016/j.fertnstert.2024.07.121
Volume 122, Issue 4, Supplement, October 2024, Page e21
Cellular senescence, a process by which cells permanently stop dividing, is a hallmark of aging. Senescent cells (SCs) accumulate in aging tissues, secreting pro-inflammatory cytokines and causing fibrosis and organ dysfunction. Treatment with senolytics (a class of drugs that selectively clear SCs) has shown widespread benefit for the prevention of age-related disorders. The aging mouse ovary displays features of cellular senescence, but it is not known whether SCs also accumulate in human ovaries. Furthermore, in clinical trials, senolytics are administered well after menopause, such that any beneficial effect of SC clearance on reproductive longevity will be missed
DIFFERENCES IN SERUM METABOLOME PROFILES IN FSHB NULL FEMALE MICE EXPRESSING WILD-TYPE OR RE-ROUTED FOLLICLE-STIMULATING HORMONE
Simone Elder MD 1, Francesca Cendali BS 1, T. Rajendra Kumar M.PHIL., M.S., PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.122
Volume 122, Issue 4, Supplement, October 2024, Page e21
Female mice expressing re-routed follicle-stimulating hormone (FSH) exhibit extended reproductive life span. Our objective was to compare serum metabolomic profiles between Fshb null mice and Fshb null mice expressing either wild-type FSH (FR) or re-routed FSH containing LH? carboxy terminus peptide (FRP). Female mice at 3 months (young) and 12 -14 months (old) of age were used for this study.
MIND-BODY INTERVENTIONS PROGRAM IMPROVES DEPRESSION, ANXIETY AND STRESS SYMPTOMS IN PATIENTS UNDERGOING FERTILITY TREATMENT
Nicole K. Callahan M.S., N.P. 1, Alice D. Domar Ph.D. 2, Jessica L. Bleess P.A.-C. 3, Alessandra J. Ainsworth M.D. 3
doi : 10.1016/j.fertnstert.2024.07.123
Volume 122, Issue 4, Supplement, October 2024, Pages e21-e22
Many people with infertility struggle to cope with the uncertainty of treatment outcomes and the associated emotional burdens of care. Mind-body interventions can improve commonly reported depression, anxiety and stress symptoms. This pilot study aimed to evaluate the effect of a mind-body intervention program, led by an Advanced Practice Provider (APP), on depression, anxiety, and fertility-related stress symptoms in symptomatic women undergoing fertility treatment.
PERSPECTIVES ON ADVANCED PRACTICE PROVIDERS (APPS) PARTICIPATION IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY (REI) DIFFERS BASED ON PRACTICE EXPERIENCE
Ashley Marie Brown MSN, APRN-CNP 1, Kathleen Devine MD 2, Elizabeth Clain M.D. 3, Rebecca Flyckt M.D. 1
doi : 10.1016/j.fertnstert.2024.07.124
Volume 122, Issue 4, Supplement, October 2024, Page e22
Collaboration with Advanced Practice Providers (APPs) in Reproductive Endocrinology and Infertility (REI) is common within REI practices nationally. This study aims to determine whether perceptions of appropriate APP practice differ based on experiences with APP/MD collaborative practice models
A RANDOMIZED CONTROLLED TRIAL(RCT) OF COUNSELING AND EDUCATIONAL METHODS ON PREIMPLATATION GENETIC TESTING FOR ANEUPLOIDY(PGT-A) FOR IVF PATIENTS
Prapti Singh D.O., M.S. 1, Karen M. Summers MPH CHES 1, Nour Chanouha M.S. 1, Renata Thoeny M.S. 1, Alithea Zorn M.S. 1, Bradley J. Van Voorhis M.D. 1, Amy E. Sparks PH.D. 1, Abey Eapen MBBS DRCOG PHD FCRI 1, Elissa Faro PH.D 1, Stacey A. Pawlak PH.D. 2, Hakan Duran M.D. 1
doi : 10.1016/j.fertnstert.2024.07.125
Volume 122, Issue 4, Supplement, October 2024, Pages e22-e23
To prospectively compare methods of education on PGT-A- using 3 groups (G), G1: REI provider counseling (REI-C) only, G2: REI-C and a written educational handout (HO) and G3: REI-C, HO, and a brief counseling session with a genetic counselor (GC) in clinic.
THE EFFECTIVENESS AND UTILITY OF LIVE PRE-TEST PGT-A GROUP GENETIC COUNSELING WEBINAR
Debra Paul MS, LCGC 1, Amy Jordan MS, LCGC 2, Cengiz Cinnioglu PhD 3, Sydney Bunshaft MS, LCGC 4, Claire Murphy Jones MS, CGC 1, Brittany-Ann Delacruz MS, LCGC 1, Francesca Zisa BS 1
doi : 10.1016/j.fertnstert.2024.07.126
Volume 122, Issue 4, Supplement, October 2024, Page e23
The objective of this study is to assess the utility and effectiveness of an optional pre-test group counseling live webinar presented by a genetic counselor in lieu of individual pre-test counseling for pre-implantation genetic testing for aneuploidy (PGT-A).
IMPACT OF STATE LEGISLATION MANDATING FERTILITY PRESERVATION COVERAGE ON FERTILITY PRESERVATION RATES IN TRANSGENDER AND GENDER NON-BINARY PATIENTS
Riley Mickelsen MD 1, Chinmay Pandit MHI 2, Emily Chang MD 1, Abigail Archibald MD 1, Cynthia Triplett MPH MA 1, Alexa Kaskowitz MD, MPH 1
doi : 10.1016/j.fertnstert.2024.07.127
Volume 122, Issue 4, Supplement, October 2024, Pages e23-e24
To describe the trends in the rate of transgender or gender non-binary (TG/NB) patients undergoing fertility preservation counseling and procedures in the three years before and after passage of Senate Bill 600 (SB600), which requires private insurance to cover initial fertility preservation costs in cases of iatrogenic infertility in the state of California.
LANGUAGE MATTERS: DIFFERENCES IN SERVICES AND POPULATIONS COVERED BY STATE FERTILITY PRESERVATION INSURANCE MANDATES
Benjamin J. Peipert MD 1, Melissa N. Montoya MD, MA 2, Joyce Reinecke J.D. 3, Kara N. Goldman M.D. 4
doi : 10.1016/j.fertnstert.2024.07.128
Volume 122, Issue 4, Supplement, October 2024, Page e24
To characterize differences among state fertility preservation (FP) insurance mandates with respect to coverage for specific FP services and patient populations, and to evaluate how these inclusions and exclusions were associated with political party alignment at time of passage.
ASSOCIATIONS BETWEEN PRE-PREGNANCY ENDOMETRIOSIS AND POSTPARTUM PSYCHIATRIC DISORDERS
Tina Yi Jin Hsieh MD, MPH 1, Werner Neuhausser M.D., PH.D. 2, James Cheng-Chung Wei MD PhD 3, Anna M. Modest Ph.D., M.P.H. 4
doi : 10.1016/j.fertnstert.2024.07.129
Volume 122, Issue 4, Supplement, October 2024, Page e24
The phenotypic and genetic association between endometriosis and psychiatric disorders is well recognized, but the correlation of endometriosis with postpartum psychiatric conditions has not been investigated.
PREVALENCE OF MENTAL HEALTH DIAGNOSES IN A RECURRENT PREGNANCY LOSS (RPL) POPULATION
Samantha L. Kruger MD 1, Sophia Miryam Schüssler-Fiorenza Rose MD, PhD 2, Brindha Bavan M.D., M.S. 3, Aleksandar Rajkovic M.D. 4, Marina Sirota PhD 5, Ruth B. Lathi MD 6
doi : 10.1016/j.fertnstert.2024.07.130
Volume 122, Issue 4, Supplement, October 2024, Page e25
RPL is a devastating diagnosis associated with high psychological stress and negative impact on long term health of affected individuals [1]. The objective of this study is to describe the effect of prior live births and number of losses on the risk of mental health diagnoses (anxiety, depression and PTSD) for RPL patients.
IMPACT OF A NURSE NAVIGATOR PROGRAM ON REFERRAL RATES AND USE OF FERTILITY PRESERVATION: A 14-YEAR RETROSPECTIVE COHORT STUDY
Kimia Sorouri M.D., M.P.H. 1, Mackenzie N. Naert M.D., M.S.C.R. 2, Zachary W. Walker M.D. 3, Andrea Lanes BSC, MSC, PHD 2, Abigail M. Kempf BA 3, Lucy Chen PhD 3, Randi H. Goldman B.S., M.D. 4, Elizabeth S. Ginsburg M.D. 5, Serene S. Srouji MD 3
doi : 10.1016/j.fertnstert.2024.07.131
Volume 122, Issue 4, Supplement, October 2024, Page e25
To determine the impact of a dedicated Nurse Navigator Program (NNP) on rate of referrals and utilization of FP services.
MEDIATING EFFECT OF PSYCHOLOGICAL RESILIENCE BETWEEN INFERTILITY-RELATED STRESS AND PSYCHOLOGICAL DISTRESS AMONG ENDOMETRIOSIS-ASSOCIATED INFERTILITY FEMALES: A STRUCTURAL EQUATION MODELING ANALYSIS
Shaoyuan Xu MD 1, Xiaoqian Chen MD 2, Renyu Wang BSc 1, Yanbin Lin BSc 1, Yuping Zhao MD 2, Xiumin Jiang MD 3
doi : 10.1016/j.fertnstert.2024.07.132
Volume 122, Issue 4, Supplement, October 2024, Pages e25-e2
Endometriosis-associated infertility females suffer from physical pain disturbance, as well as pressure of pregnancy uncertainty, marriage quality, and public opinion, resulting in significant adverse effects on their psychology. This study aimed to evaluate the level of psychological distress, and examine whether psychological resilience plays a mediating role in the relationship between infertility-related stress and psychological distress among endometriosis-associated infertility females
WHAT DO PATIENTS ACTUALLY WANT WHEN PROVIDING SEMEN SAMPLES? A MIXED METHODS SURVEY ASSESSING PATIENTS’ SEMEN COLLECTION ROOM EXPERIENCES AND PREFERENCES
Kristian M. Black M.D., M.S. 1, Daniela Wittmann Ph.D, LMSW 1, Mary Byrnes Ph.D. 2, Catherine S. Nam M.D. 1, Adrienne N. Shami M.D., Ph.D 3, Samantha B. Schon M.D., M.S. 1, Dana A. Ohl MD 1, James M. Dupree M.D., M.P.H 1
doi : 10.1016/j.fertnstert.2024.07.140
Volume 122, Issue 4, Supplement, October 2024, Page e26
The conventional approach for obtaining semen specimens for infertility evaluations is characterized by using a private "collection room” with visual erotic material (VEM). As demographic shifts occur among patient populations, infertility providers must foster inclusive and positive patient collection room experiences. Therefore, we surveyed patients using semen collection rooms to discover their preferred methods of accessing VEM, preferred VEM categories, and qualitative feedback about their semen collection room experiences
SCROTAL ULTRASOUND CAN BE USED AS AN ADJUNCT TEST TO RULE IN VARICOCELES FOR PATIENTS BEING EVALUATED BY MALE REPRODUCTIVE UROLOGISTS WITH TELEMEDICINE
Catherine S. Nam M.D. 1, Alyssa M. Hardin MD 2, Juan J. Andino MD, MBA 3, Stephanie Daignault-Newton M.S. 4, Dana A. Ohl MD 1, James M. Dupree M.D., M.P.H 1
doi : 10.1016/j.fertnstert.2024.07.141
Volume 122, Issue 4, Supplement, October 2024, Pages e26-e27
With increasing use of telemedicine and limited supply of reproductive urologists, more patients are being evaluated for male infertility using telemedicine. Many urologists are using scrotal ultrasound (US) to replace physical exams in telemedicine, but it remains unknown whether US can reliably diagnose varicocele in the setting of male infertility. Therefore, we examined the agreement of varicoceles findings between a physical exam and scrotal US.
CRYOPRESERVED TESTICULAR SPERMATOZOA AMONG PATIENTS WITH AZOOSPERMIA
Roy Bitan MD, MHA, Michal Youngster MD, Ariel Hourvitz M.D., Itai Gat MD
doi : 10.1016/j.fertnstert.2024.07.142
Volume 122, Issue 4, Supplement, October 2024, Page e27
To investigate cryopreserved testicular spermatozoa among patients with azoospermia
CHARACTERISTICS OF OLDER FATHERS IN THE UNITED STATES: DATA FROM THE NATIONAL SURVEY OF FAMILY GROWTH
James Stinson III MD, MS 1, Shufeng Li MS 2, Michael Eisenberg M.D. 3
doi : 10.1016/j.fertnstert.2024.07.143
Volume 122, Issue 4, Supplement, October 2024, Page e27
To evaluate the characteristics of older fathers (defined by ASRM as ? 40 years old) including demographic, reproductive, socioeconomic, and parenting factors
THE ASSOCIATION BETWEEN SOCIOECONOMIC DEPRIVATION STATUS AND PM2.5 EXPOSURE AND SEMEN PARAMETERS AMONG MEN PRESENTING FOR FERTILITY EVALUATION
Luis Carlos Arthur Gago Jr. BSI 1, Daniel R. Greenberg M.D. 2, Sai Kaushik Shankar Ramesh Kumar MS 2, Robert E. Brannigan M.D. 3, Joshua J. Horns PhD 4, Joemy M. Ramsay PhD 4, James M. Hotaling M.D., M.S. 4, Joshua A. Halpern M.D., M.S. 3
doi : 10.1016/j.fertnstert.2024.07.144
Volume 122, Issue 4, Supplement, October 2024, Pages e27-e28
To evaluate the impact of socioeconomic deprivation status and ambient fine particulate matter (PM2.5) exposure on semen parameters among a large cohort of men undergoing fertility evaluation
GEOGRAPHIC TRENDS OF ENVIRONMENTAL EXPOSURES FOR MEN PURSUING SEMEN ANALYSIS
Trevor Maloney DO 1 2, Trimble Spitzer M.D. 2, Daniel Nolte MS 3, Stacey A. Kenfield SM, ScD 4, Daniel Civello BS 5, Andre Belarmino BA, MD 6, James F. Smith M.D., M.S. 7, Dorota J. Hawksworth M.B.A., M.D. 8
doi : 10.1016/j.fertnstert.2024.07.145
Volume 122, Issue 4, Supplement, October 2024, Page e28
Environmental toxins are commonly thought to impair spermatogenesis through low-dose, chronic exposures. Existing studies primarily review large retrospective populations, which do not account for potential regional differences. This study aims to describe environmental exposures and potential geographical trends in both fertile and subfertile men residing in the United States.
COMET-PCOS: RANDOMIZED CONTROLLED TRIAL OF ORAL CONTRACEPTIVE PILLS (OCPS), METFORMIN OR BOTH FOR 24WEEKS IN WOMEN WITH PCOS AND OBESITY SHOWS NO DIFFERENCE IN PREVALENCE OF METABOLIC SYNDROME
Anuja Dokras MD, MHCI, PhD 1, Allen R. Kunselman M.A. 2, Christina M. Stetter B.S. 2, William C. Dodson M.D. 3, Christos Coutifaris M.D., PH.D. 4, Richard S. Legro M.D. 3
doi : 10.1016/j.fertnstert.2024.07.148
Volume 122, Issue 4, Supplement, October 2024, Page e28
Reproductive age women with PCOS have increased cardiovascular disease (CVD) risk and the negative impact of first line medications, namely oral contraceptive pills (OCPs), on individual CVD risk factors such as glucose, lipids and insulin resistance is reported to be mixed. To better ascertain the effects of common PCOS medications on CVD risk at a young age, we examined the impact of OCPs, metformin and the combination on prevalence of Metabolic Syndrome (MetSyn), a constellation of risk factors that collectively predict risk of future diabetes and CVD
2, 4, 6, 8 HOW MANY MEASURES DOES IT TAKE? ACCURACY OF FINAL MENSTRUAL PERIOD (FMP) PREDICTIONS USING REPEATED MEASURES OF ANTIMULLERIAN HORMONE (AMH) FROM THE STUDY OF WOMEN ACROSS THE NATION (SWAN)
Mary D. Sammel ScD 1, Laura Katherine Kaizer MPH 2, Elizabeth Juarez-Counga PhD 1, Xin Jin PhD 1, Joel Finkelstein MD 3, Genevieve S. Neal-Perry M.D., Ph.D. 4, Anthony Morrison B.Sc., MBA 5, Nanette Santoro M.D. 6
doi : 10.1016/j.fertnstert.2024.07.149
Volume 122, Issue 4, Supplement, October 2024, Pages e28-e29
Anti-Mullerian hormone (AMH) has proven to be a useful tool for prediction of the timing of the final menstrual period (FMP), however a single AMH determination has limitations in its ability to predict ovarian depletion. In this study we evaluate the minimum number of AMH measures, along with participants characteristics, to accurately predict timing of the FMP.
ASSOCIATION OF POLYCYSTIC OVARIAN SYNDROME WITH EXCESSIVE GESTATIONAL WEIGHT GAIN
Rachel Solmonovich MD 1, Frank I. Jackson MD 1, Matthew J. Blitz MD, MBA 2, Gabriel San Roman M.D. 1, Randi H. Goldman B.S., M.D. 1
doi : 10.1016/j.fertnstert.2024.07.150
Volume 122, Issue 4, Supplement, October 2024, Page e29
To determine differences in the rates of excessive gestational weight gain (EGWG) among pregnant patients with and without polycystic ovarian syndrome (PCOS)
THE ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND CHANGES IN QUALITY-OF-LIFE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
Courtney Murphy M.D. 1, Rachel Paul MPH 2, Madison Copeland B.A. 2, Aileen Portugal MD 3, Tessa Madden MD, MPH 4, Patricia T. Jimenez B.A., M.D. 5
doi : 10.1016/j.fertnstert.2024.07.151
Volume 122, Issue 4, Supplement, October 2024, Pages e29-e30
Patients with PCOS have an increased prevalence of chronic conditions including depression. Our objective was to measure changes in patients’ PCOS-related quality of life (QOL) before and after initiating a patient-centered PCOS treatment plan stratified by positive and negative depression screen.
IS UNDETECTABLE ANTIMULLERIAN HORMONE (AMH) REVERSIBLE? AN ANALYSIS OF REBOUND IN AMH AND ESTRADIOL (E2) IN THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION (SWAN)
Kelly S. Acharya M.D. 1, Bethelhem A. Shiferaw MPH 2, Laura Katherine Kaizer MPH 3, Laura Bozzuto M.D., M.S. 4, Joel Finkelstein MD 5, Genevieve S. Neal-Perry M.D., Ph.D. 6, Arun Karlamangla MD 7, Anthony Morrison B.Sc., MBA 8, Nanette Santoro M.D. 9, Mary D. Sammel ScD 10
doi : 10.1016/j.fertnstert.2024.07.152
Volume 122, Issue 4, Supplement, October 2024, Page e30
AMH disappearance at menopause is believed to be permanent. However, a subset of SWAN participants who had annual AMH measured up to or after their final menstrual period (FMP) demonstrated a notable “rebound” of AMH. We sought to characterize the prevalence of AMH rebound, determine its relationship to change in estradiol (E2), and identify associated characteristics
THE ASSOCIATION BETWEEN PRIMARY OVARIAN INSUFFICIENCY AND INCREASED MULTIMORBIDITY IN A LARGE PROSPECTIVE COHORT
Abi Kirubarajan MD MSc 1, Sarker Sohel PhD 2, Alexandra Mayhew PhD 2, Lauren E. Griffith PhD 3, Parminder Raina PhD 3, Alison Shea MD, PhD 3
doi : 10.1016/j.fertnstert.2024.07.153
Volume 122, Issue 4, Supplement, October 2024, Pages e30-e31
To describe the prevalence of multimorbidity among individuals with premature ovarian insufficiency (POI) and early menopause, in comparison to normal age of menopause
SELF-ASSESSMENT OF HEALTHCARE WORKER COMMUNICATION WITH LANGUAGE DIVERSE PATIENTS IN OBSTETRICS AND GYNECOLOGY
Thammatat Vorawandthanachai MD 1, Janet Stein MD, MS 1, Cindy Ann Brantmeier PhD 2
doi : 10.1016/j.fertnstert.2024.07.154
Volume 122, Issue 4, Supplement, October 2024, Page e31
In studying language as a social determinant of health, few studies have looked at the self-assessment of healthcare workers’ (HCW) perceptions of their communication with language diverse patients (LDP) who prefer non-English languages. This study’s questions include: How do HCW in Ob/Gyn evaluate their own preparedness to communicate about specific OB concepts or topics with English speaking and LDP? Are there differences in assessments of communications of English-speaking and bilingual HCW? How do HCW perceive their use of interpreters?
UTILIZATION OF LOW-COST PADS ALPHA FETOPROTEIN DETECTION PADS TO SUPPLEMENT DIAGNOSIS OF RUPTURE OF MEMBRANES IN LOWER RESOURCE SETTINGS
Thammatat Vorawandthanachai MD 1, Amir Mor MD PhD 2, Jiahua Chen DO 1
doi : 10.1016/j.fertnstert.2024.07.155
Volume 122, Issue 4, Supplement, October 2024, Pages e31-e32
Due to limited resources and fewer health centers in developing countries, self-tests can help patients diagnose critical conditions like ruptured membranes. Nitrazine-containing pads, available over the counter, use pH levels to detect ruptured membranes, which are often inaccurate with low specificity due to urine’s physiological alkalinity. A more specific technique to reliably detect amniotic fluid absorbed in a pad can be the use of ROM+ or Amnisure (FDA approved lateral flow immunoassay strips) as well as Alpha-fetoprotein (AFP) strips embedded in a pad [1,2]. This study addressed the following questions: 1) Is Nitrazine a reliable tool to differentiate amniotic fluid from maternal urine? 2. Can FDA approved test strips for rupture of membranes (Amnisure, and ROM Plus) be embedded in pads and serve as a reliable tool for amniotic fluid leakage? 3. What is the comfort level of using a pad with an embedded test strip?
RACIAL AND ETHNIC DIFFERENCES IN GESTATIONAL CARRIERS: ASSESSMENT OF PREGNANCY CHARACTERISTICS AND OBSTETRIC MORBIDITY AT DELIVERY
Aaron Masjedi M.D. 1, Zachary S. Anderson M.D. 1, Katherine Erickson BA, MS 1, Laurel S. Aberle MD 2, Rachel S. Mandelbaum M.D. 1, Richard J. Paulson M.D., M.S. 1, Joseph G. Ouzounian MD, MBA 1, Koji Matsuo MD, PhD 1
doi : 10.1016/j.fertnstert.2024.07.156
Volume 122, Issue 4, Supplement, October 2024, Page e32
Significant racial disparities with regard to maternal morbidity and mortality exist in the United States. Surrogate gestational carriers (GCs) are typically selected based on favorable risk profiles for pregnancy and receive prenatal care from an early gestational age. This population is an important model to assess racial disparities in maternal morbidity and mortality. Our objective was to investigate the impact of race on maternal outcomes in GC pregnancies.
FACTORS ASSOCIATED WITH FERTILITY TREATMENT DISCONTINUATION AMONG DONOR SPERM RECIPIENTS
Jonathan M. Konel MD MHS 1, Kerry S.J. Flannagan PhD 2, Jiarui Wang M.S. 2, Stephanie Beall M.D., PH.D. 3, Jerrine R. Morris B.S., M.D., M.P.H 3
doi : 10.1016/j.fertnstert.2024.07.157
Volume 122, Issue 4, Supplement, October 2024, Page e32
The utilization of donor sperm for fertility treatment has almost doubled from 3.8% to 6.2%, with the greatest increase seen among same sex female couples and single women. While up to 60% of all women, regardless of orientation or marital status, discontinue fertility treatment, little is known about factors associated with treatment discontinuation among donor sperm recipients. With the expanded definition of infertility, understanding the barriers certain populations face is paramount. The goal of this study was to investigate factors associated with treatment discontinuation among donor sperm recipients.
ASSOCIATION BETWEEN SOCIOECONOMIC DEPRIVATION, LIFE EXPECTANCY AND SERUM AMH LEVELS IN A COHORT OF INFERTILE WOMEN
Alexander Marion MD, Kristina C. Hawkins M.D., Abdelmoneim I. Younis D.V.M., PH.D
doi : 10.1016/j.fertnstert.2024.07.158
Volume 122, Issue 4, Supplement, October 2024, Pages e32-e33
Fertility and health vary across different locations. It is important to assess how fertility levels differ in smaller geographic areas for it is known that these units can show health disparities more accurately than larger ones. The area deprivation index (ADI) accomplishes this as it measures the level of socioeconomic disadvantage in a local geographic area. The objective of this study was to investigate the relationship between socioeconomic hardship, life expectancy (LE), and anti-Müllerian hormone (AMH) levels.
UTILIZING MAIL-IN SEMEN ANALYSIS TO IMPROVE TIME TO COMPLETION OF THE INFERTILITY WORKUP IN THE UNDERSERVED POPULATION: A RANDOMIZED CONTROL TRIAL
Kimberly Yau M.D. 1, Adriana J. Wong M.D., M.P.H 1, Marisa C. Gigg M.D. 1, Laurel S. Aberle MD 1, Kaitlin A. Doody M.D. 1, Sharon A. Winer M.D., M.P.H 2
doi : 10.1016/j.fertnstert.2024.07.159
Volume 122, Issue 4, Supplement, October 2024, Page e33
This quality improvement study aims to evaluate if mail-in semen analysis (SA) testing will reduce the time to completion of the male infertility workup at a safety net hospital when compared to the current practice of providing patients with a list of outside fertility clinics for traditional SA testing
COST-CONSCIOUS FERTILITY CARE: NATURAL AND STIMULATED INTRAUTERINE INSEMINATION CYCLES RESULT IN SIMILAR ONGOING PREGNANCY RATES FOR FEMALE SAME-SEX COUPLES
Vania Nwokolo M.D. 1, Kassie Jean Bollig M.D., M.S.C.E. 2
doi : 10.1016/j.fertnstert.2024.07.160
Volume 122, Issue 4, Supplement, October 2024, Pages e33-e34
Female same-sex couples must utilize fertility assistance to conceive, and the optimal non-IVF treatment practice yielding the highest ongoing pregnancy rate is not clear. Despite a steady increase in the utilization of reproductive services, insurance coverage may be particularly challenging as many carriers require evidence of infertility or heterosexual marriage to qualify for coverage. Same-sex couples also take on additional costs for donor gametes or other third-party services. Research focused on evaluating treatment plans that minimize cost while optimizing outcomes among this population is needed. The objective of this study is to compare the ongoing clinical pregnancy rate among female same-sex couples who are undergoing IUI alone to those undergoing ovulation induction with IUI.
EVALUATING THE IMPACT OF PHYSICAL ACTIVITY AND STRESS ON FROZEN EMBRYO TRANSFER CYCLE OUTCOMES: THE STEP AND STRESS TRACKING TO ESTIMATE PREGNANCY (SSTEP) TRIAL
Emily A. Jacobs M.D. 1, Karen M. Summers MPH CHES 1, Bradley J. Van Voorhis M.D. 2
doi : 10.1016/j.fertnstert.2024.07.161
Volume 122, Issue 4, Supplement, October 2024, Page e34
To investigate the relationship between objectively measured physical activity and stress on standard hormone therapy replacement (HRT) frozen embryo transfer (FET) outcomes
THE IMPACT OF A PRIOR CESAREAN DELIVERY ON IVF OUTCOMES: A REGISTRY-BASED COHORT STUDY IN ONTARIO, CANADA
Isabelle Létourneau MD 1, Jenna Gale B.SC., M.D. 2
doi : 10.1016/j.fertnstert.2024.07.162
Volume 122, Issue 4, Supplement, October 2024, Page e34
The objective of this study was to estimate if prior cesarean delivery decreases pregnancy rates with IVF.
EMBRYO MORPHOLOGY ACCORDING TO SOCIETY FOR ASSISTED REPRODUCTIVE TECHNOLOGY (SART) CRITERIA AFFECTS LIVE BIRTH RATE IN SINGLE EUPLOID FROZEN EMBRYO TRANSFERS
Ioanna Agatha Katehis M.D., M.P.H. 1, Sebastian J. Geraci D.O. 1, Anand Rajan M.P.H. 2, Alicia J. Arnott B.S. 1, Rani Fritz D.O., Ph.D. 3, Vasilios Goudas M.D. 3
doi : 10.1016/j.fertnstert.2024.07.163
Volume 122, Issue 4, Supplement, October 2024, Pages e34-e35
To evaluate differences in outcome between good and fair grade embryos by SART grading system after single frozen euploid blastocyst transfer. To date no prior study has evaluated outcomes with the SART morphological grading system
ADVANCED SPERM AGE ≥50 YEAR IS ASSOCIATED WITH AN INCREASE IN SEGMENTAL ANEUPLOIDY RATES: A MULTI-SITE DONOR OOCYTE POPULATION STUDY OF 2124 BIOPSIED EMBRYOS WITH PGTSEQ
Francesca Barrett M.B.A., M.D. 1, Amanda D. Kadesh M.D., M.S. 2, Yiping Zhan Ph.D 3, Pavan Gill MD 1, Blake Vessa M.D. 4, Christine V. Whitehead MS, B.S.N., R.N. 1, Nicolas Garrido Puchalt M.Sc., Ph.D. 5, Emily Mounts M.S. 3, Emre Seli M.D. 1, Marie D. Werner B.A., H.C.L.D, M.D. 1, Chaim Jalas N/A 6, Jason M. Franasiak H.C.L.D, M.D. 1
doi : 10.1016/j.fertnstert.2024.07.164
Volume 122, Issue 4, Supplement, October 2024, Page e35
To determine if sperm age is associated with rates of chromosomal abnormality in oocyte donor-derived embryos using a validated preimplantation genetic testing for aneuploidy (PGT-A) platform.
“BLIND” OVULATORY TRIGGER COMPARED TO STANDARD OVULATORY TRIGGER DURING IN VITRO FERTILIZATION CYCLES IS ASSOCIATED WITH COMPARABLE OOCYTE RETRIEVAL OUTCOMES
Peter Kovacs M.D., PH.D. 1, Chantal Kinsey BS 2, Phillip A. Romanski M.D., M.SC. 3, Szabolcs Matyas PhD 1, Yao Lu M.D. 4, Amanda Vozzola MD 5, G. Wright Bates JR M.D. 6, Steven R. Lindheim M.D. 5
doi : 10.1016/j.fertnstert.2024.07.165
Volume 122, Issue 4, Supplement, October 2024, Pages e35-e36
Affordability of in vitro fertilization (IVF) treatment has been shown to be correlated with access to infertility care. Given follicular growth occurs at a predictable rate, some have used a “blind trigger” (BT, no ultrasound/ blood work on trigger day) approach as a patient friendly and cost-effective maneuver, thus we evaluated its impact on IVF outcomes compared to conventional monitoring
HOW ABOUT REPLICATING THE MALE GENOME?
Philip Xie B.SC., Stephanie Cheung M.S., Angela Bryanne De Jesus B.A., Zev Rosenwaks M.D., Gianpiero D. Palermo M.D., PH.D.
doi : 10.1016/j.fertnstert.2024.07.167
Volume 122, Issue 4, Supplement, October 2024, Page e36
It would be of relevance to obtain information on the specific genomic makeup of an individual spermatozoon by making a copy of it, and this would be beneficial for men with an extremely low number of spermatozoa. In this study, we aim to replicate a specific male gamete by injecting an individual spermatozoon into an enucleated oocyte.
THE USE OF AMD3100 FOR BONE MARROW DERIVED MESENCHYMAL STEM CELLS MOBILIZATION IN THE TREATMENT OF ASHERMAN’S SYNDROME
Valerie A. Flores M.D. 1 2, Pablo Delis MD 3, Ramanaiah Mamillapalli Ph.D. 4, Hugh S. Taylor M.D. 5
doi : 10.1016/j.fertnstert.2024.07.168
Volume 122, Issue 4, Supplement, October 2024, Pages e36-e37
Asherman’s syndrome (AS) is characterized by intrauterine adhesions/fibrosis, resulting from damage to the endometrial basalis layer. The consequences of AS include infertility, recurrent pregnancy loss, preterm rupture of membranes, and placental abruption. Hysteroscopic adhesiolysis rarely restores endometrial function sufficiently, thus there is a need for more effective treatments. Bone marrow-derived mesenchymal stem cells (BMD-MSCs) circulate systemically and contribute to tissue repair/regeneration of various organs, suggesting they may serve as a source of progenitor cells for endometrial regeneration. Increasing the supply of BMD-MSCs to the endometrium may treat AS by allowing for regeneration/replenishment of endometrial progenitor cells. Mobilization of autologous BMD-MSCs using AMD3100, a CXC-motif-receptor-4 antagonist, is approved for bone marrow stem cells transplantation. We aimed to determine if the optimal timing of AMD 3100 administration—based on CXCL12 production—would better recruit BMD-MSCs in a murine model of severe AS, and restore functioning endometrium/fertility
AUTOLOGOUS CELL THERAPY WITH CD133+ BONE MARROW-DERIVED STEM CELLS REVERT MODERATE/SEVERE ASHERMAN'S SYNDROME: PHASE I/II TRIAL
Xavier Santamaria MD, PhD 1, Raul Pérez-Moraga M.Sc 2, Roson Beatriz PhD 3, Javier González Fernández MSc 4, Ramon Aurell Medical Director 5, Maria Pardo PhD 6, Juan Jose Torrent MD 7, Felipe Vilella PhD 8 9, Carlos Simon MD; PhD 10
doi : 10.1016/j.fertnstert.2024.07.169
Volume 122, Issue 4, Supplement, October 2024, Page e37
Asherman’s Syndrome (AS) is a rare disease (ORPHA: 137686) defined by the presence of intrauterine adhesions (IUAs) resulting in menstrual abnormalities, pelvic pain, infertility, and abnormal placentation
EDITING THE HAPLOID GENOME OF ANDROGENETIC EMBRYONIC STEM CELL
Eros Lari B.S., Angela Bryanne De Jesus B.A., Philip Xie B.SC., Zev Rosenwaks M.D., Gianpiero D. Palermo M.D., PH.D.
doi : 10.1016/j.fertnstert.2024.07.170
Volume 122, Issue 4, Supplement, October 2024, Pages e37-e38
The ability to edit the genome of a gamete is the earliest and most effective way to uniformly transmit the desired genotype to a progeny. We aim at investigating the feasibility of editing a specific gene in haploid androgenetic mouse embryonic stem cells (haESCs) using CRISPR-Cas9
CRISPR/CAS9 BASE EDITING ENABLES PRECISE GENE EDITING IN PREIMPLANTATION HUMAN EMBRYOS WITHOUT CHROMOSOMAL CHANGES
Diego Marin PH.D. 1, Stepan Jerabek PhD 2, Marcos Kulmann MSc 2, Jia Xu PhD 1, Julie Sung BA 2, Jimin Kim BS 2, Melisa Isado BS 2, Nathan R. Treff PhD, HCLD 1, Dieter Egli PhD 2
doi : 10.1016/j.fertnstert.2024.07.171
Volume 122, Issue 4, Supplement, October 2024, Page e38
Cas9-based tools allow the introduction of precise genetic lesions to interrogate DNA repair outcomes as well as edit the genome in disease-relevant genes. Double-strand breaks (DSBs) introduced by CRISPR/Cas9 result in undesired segmental or whole-chromosome changes in early human embryos. This study aims to evaluate the DNA repair outcomes of mismatches and DNA nicks introduced using Cas9 nickase in human embryos.
GENERATION OF BLASTOCYST-LIKE STRUCTURES VIA 3D ACOUSTIC TWEEZERS
Maria Carolina Zimara M.S. 1, Kun Liu MS 2, Toshihiko Ezashi PhD 1, William B. Schoolcraft M.D. 1, Xiaoyun Ding PhD 2, Ye Yuan PhD 1
doi : 10.1016/j.fertnstert.2024.07.172
Volume 122, Issue 4, Supplement, October 2024, Page e38
Human blastoids are a scalable and ethical model for studying human development. Here, we report a novel, contact-free Acoustic method for human blastoid generation with less cellular stress, improved efficiency, and improved blastoid quality compared to the standard AggreWell method
EIGHT YEARS OF UTERUS TRANSPLANTS IN THE UNITED STATES: UPDATE ON SURGICAL, REPRODUCTIVE, NEONATAL, AND CHILD DEVELOPMENTAL OUTCOMES
Leigh A. Humphries MD 1, Liza Johannesson MD, PhD 2, Paige M. Porrett MD, PhD 3, Giuliano Testa MD 2, Jessica R. Walter MD, MSCE 4, Elliott G. Richards MD, PhD 5, Kathleen O'Neill MD 1
doi : 10.1016/j.fertnstert.2024.07.174
Volume 122, Issue 4, Supplement, October 2024, Pages e38-e39
About half of global experience with uterus transplant (UTx) has occurred in the United States, with 48 transplants completed as of early 2024. This study is a longitudinal report from the United States Uterus Transplant Consortium on the surgical, reproductive, neonatal, and child developmental outcomes after UTx in the U.S. over the past 8 years
PREOPERATIVE HORMONE USE AND SURGICAL COMPLEXITY IN ENDOMETRIOSIS CASES
Margaret A. Rush MD 1, Leigh A. Humphries MD 1, Nathan C. Koelper MPH 1, Meridith Pollie MD 2, Shefali Setia Verma PhD 2, Suneeta Senapati MD MSCE 2
doi : 10.1016/j.fertnstert.2024.07.175
Volume 122, Issue 4, Supplement, October 2024, Page e39
Hormonal suppression therapy is commonly used to treat endometriosis, yet its role in pre-operative optimization of disease is unclear. Using the 2021 American Association of Gynecologic Laparoscopists endometriosis classification system (AAGL score) as a measure of surgical complexity (1), our objective is to understand how pre-operative hormone use can influence disease noted at surgery for endometriosis.
INCIDENCE AND MANAGEMENT OF PELVIC PAIN IN PATIENTS WITH OBSTRUCTIVE AND NON-OBSTRUCTIVE MULLERIAN ANOMALIES
Margaret A. Rush MD 1, Hannah S. Foster MD, MA 1, Leigh A. Humphries MD 1, Varshini Babu BS, MPH 2, Suditi Shyamsunder BS 2, Monica A. Mainigi MD 3
doi : 10.1016/j.fertnstert.2024.07.176
Volume 122, Issue 4, Supplement, October 2024, Pages e39-e40
Pelvic pain is common among patients with a Mullerian anomaly; to date, the presentation and management of pelvic pain has been described only in case reports or small case-series. The objective of this study is to report the incidence of pelvic pain at presentation among patients with obstructive and non-obstructive Mullerian anomalies, and to describe the management of pelvic pain in this population
CONGENITAL COMPLEX UTERINE ANOMALIES (CUA) CARRY COMPLEX COMPLICATIONS: AN EVALUATION OF ART OUTCOMES
Keizra Mecklai MD MBA 1, Elise Heisler MD 2, Emily Michelle Weidenbaum MD 3, David H. McCulloh PH.D. 4, Jacquelyn Shaw M.D. 3, Mary Elizabeth Fino M.D. 3, Christopher Eswar M.D. 5, Jennifer K. Blakemore MD, MSC 3
doi : 10.1016/j.fertnstert.2024.07.177
Volume 122, Issue 4, Supplement, October 2024, Page e40
The 2021 Mullerian Anomalies Classification reset the bar on describing CUA.1 However, there is little understanding of CUA reproductive capacity and less on ART outcomes. Many CUA patients (pts) undergo CUA repair – making counseling on expected outcomes, such as clinical pregnancy, live birth (LB) or spontaneous loss rates (SAB) difficult. Our objective was to examine the ART outcomes of pts with CUA at our center
CARBON FOOTPRINT IN GYNECOLOGIC SURGERY: SURVEY OF SURGEON PERSPECTIVES ON ENVIRONMENTAL WASTE IN THE OPERATING ROOM
Emma Gargus M.D., Ph.D. 1, Kaia M. Schwartz M.D. 2, Amy Park M.D. 3, Elliott G. Richards MD, PhD 3
doi : 10.1016/j.fertnstert.2024.07.178
Volume 122, Issue 4, Supplement, October 2024, Pages e40-e41
To evaluate gynecologic surgeons’ experiences, perceptions, and willingness to change with regards to environmental waste in the operating room (OR), given the increased utilization of single use instrumentation in reproductive laparoscopy and hysteroscopy that contributes to health sector greenhouse gas emissions.
ECONOMIC BURDEN OF INFERTILITY IN WOMEN FOLLOWING INTRAUTERINE SURGERY: A RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA
Pietro Bortoletto MD, MSc 1, Coby Martin BSc, MSc 2, Onkar Kshirsagar BSc, MSc 2, Dhruv Sobti BA, MA 2, Mrinmoy Pratim Bharadwaz BSc, MSc, MPhil 3, Jatinder Kumar MPharm BSc 2, Jared Miller BSc, MSc 2, Ruihong Wang BA, MSc 2, Ian Bruce Feldberg BEng (Hons) 4, Malcolm G. Munro MD, FRCSC, FACOG, FRCOG (ad eundem) 5 6
doi : 10.1016/j.fertnstert.2024.07.179
Volume 122, Issue 4, Supplement, October 2024, Page e41
Evaluate and compare the direct economic costs of infertility-related services in a cohort of women with previous hysteroscopic intrauterine adhesiolysis and compare them to those with and without other types of transcervical intrauterine surgery
DEVELOPMENT OF A VAGINAL DILATOR DEVICE AND A HOME INSEMINATION DEVICE FOR CIS- AND TRANSGENDER PEOPLE, BASED ON THE ACTUAL ANATOMY OF THE PELVIS
Eman Dadashian MD 1, Sandeep Singh Sandhu BA, MBChB 2, Samhita Mallavarapu BS 2, Shannon Smith MD, MPH 2, Maurice Marcel Garcia MD, MAS 2
doi : 10.1016/j.fertnstert.2024.07.181
Volume 122, Issue 4, Supplement, October 2024, Page e41
Individuals undergoing vaginoplasty with canal creation must undertake life-long self-dilation and douching to maintain canal patency and hygiene. Commercially available dilators and douches are designed for cisgender anatomy, and are either straight, or, have an abrupt upward curve at the tip, inconsistent with neovaginal canal anatomy, which lacks the elasticity of a cisgender woman’s vagina, making it sensitive to dilator shape, and douche nozzle length. In addition, many LGBTQ+ individuals with a uterus seek pregnancy without a male sexual partner, but few devices exist for this population
IMPROVING OVULATION TRIGGER TIMING WITH ARTIFICIAL INTELLIGENCE (AI) TO INCREASE FROZEN EMBRYO YIELD DURING OVARIAN STIMULATION CYCLES
Rodolfo Garcia Sanchez B.S., M.SC., PHARM.D. 1, Nayeli Perez Padilla M. SC 2, Frank D. Yelian M.D., PH.D. 1, Omar Avalos PhD 2, Jorge Galvez PhD 2, Minglei Bian PH.D. 3, Liang Yu PhD 4, Yimin Shu Ph.D., M.D. 5, Ming Feng B.S. 6
doi : 10.1016/j.fertnstert.2024.07.182
Volume 122, Issue 4, Supplement, October 2024, Pages e41-e42
Develop an AI method to identify the optimal time to trigger oocyte maturation within a three-day window to maximize frozen embryo yield during minimal ovarian stimulation in In vitro fertilization (IVF) cycles.
THE EFFECTS OF SURGICAL PROCEDURE VS PLATELET-RICH PLASMA ON OVARIAN FOLLICULAR ACTIVATION AND BIOMECHANICAL CHANGES USING EXPERIMENTAL SHEEP MODEL: A PILOT STUDY
Marta Méndez Bsc 1, Francesc Fabregues MD 2, Jose Arroyo MD, PHD 3
doi : 10.1016/j.fertnstert.2024.07.183
Volume 122, Issue 4, Supplement, October 2024, Page e42
The objective of the study was to analyze the ovarian follicular activation capacity of a surgical procedure (Whole ovary laparoscopic incision-WOLI and intraovarian administration of platelet-rich plasma (PRP), and their relationship with ovarian biomechanical changes using an experimental ovine model to gain insights into the potential follicular activation pathways triggered by each strategy
ONE-STEP WARMING PROTOCOL FOR VITRIFIED BLASTOCYSTS RESULTS IN SIGNIFICANT REDUCTION OF WARMING TIME WITH NO DIFFERENCE IN CRYOSURVIVAL
Chelsey Audra Leisinger PH.D., H.C.L.D. 1, Matthew Timothy Pettit MS 2, William B. Schoolcraft M.D. 1, Rebecca Holmes D.PHIL., H.C.L.D 3, Jason E. Swain PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.184
Volume 122, Issue 4, Supplement, October 2024, Page e42
To evaluate the time savings and post warm survival after implementation of a one-step blastocyst warming approach compared to a conventional multi-step approach for vitrified blastocysts in a multi-site IVF network
OVARIAN SUPPORT CELL-ASSISTED IN VITRO MATURATION OF IMMATURE OOCYTES FROM TRUNCATED HORMONAL STIMULATION USED IN DONOR EGG CYCLES
Sabrina Piechota B.SC. 1, Maria Marchante PhD 1, Ferran Barrachina PhD 2, Camila Julia Carlos Barron B.S. 3, Paula Ricra B.S. 4, Pilar Pino BSc 5, Jazmin Meza BSc. 5, Wendy Jackeline Montanchez Hilares B.S. 5, Enrique Noriega M.D. 5, Cesar Reategui M.D. 5, Luis Noriega-Portella MD. 5 6, Pamela Villanueva MD, PhD 7, Luis Guzman PhD. 5, Christian Clark Kramme PhD 2
doi : 10.1016/j.fertnstert.2024.07.185
Volume 122, Issue 4, Supplement, October 2024, Page e43
We have previously shown that in vitro maturation (IVM) using human induced pluripotent stem cell (hiPSC)-derived ovarian support cells (OSC) improves the maturation rates of immature cumulus oocyte complexes (COCs) from abbreviated hormonal stimulations, outperforming commercially available IVM solutions and yielding healthy euploid blastocysts. In the current case series, we show the successful application of OSC-IVM coupled with abbreviated hormonal stimulation as an alternative protocol to conventional stimulation for donor egg cycles.
ASSESSMENT OF HUMAN OVARIAN STIFFNESS USING SHEAR WAVE ELASTOGRAPHY (SWE) AS A NON-INVASIVE BIOMARKER OF REPRODUCTIVE AGING
Tomiris Atazhanova MD, MSc 1, Emily Zaniker B.A. 2, Alexis Trofimchuk M.S. 3, Lydia Hughes MD 4, Man Zhang MD, PhD 5, Elnur Babayev M.D., M.SC. 1, Francesca E. Duncan PhD 2
doi : 10.1016/j.fertnstert.2024.07.186
Volume 122, Issue 4, Supplement, October 2024, Page e43
The human ovary is one of the first organs to age. The mammalian ovarian microenvironment or parenchyma becomes fibro-inflammatory and stiff with age, which may negatively impact follicle development, ovulation, and gamete quality. Human ovarian stiffness may, therefore, be a biomarker of reproductive aging. The objective of this study was to use shear wave elastography (SWE) to evaluate ovarian stiffness and its association with reproductive aging parameters
SINGLE EUPLOID EMBRYO TRANSFERS IN PATIENTS UTILIZING PGT-M: IS PARITY ASSOCIATED WITH OUTCOMES?
Johanna A. Suskin MD 1, Keri Bergin B.S., M.D. 2, Morgan Baird MPH 3, Joseph A. Lee BA 3, Matthew A. Lederman M.D. 3, Alan B. Copperman M.D. 3, Rachel B. Danis M.D. M.S 3
doi : 10.1016/j.fertnstert.2024.07.187
Volume 122, Issue 4, Supplement, October 2024, Page e44
Preimplantation genetic testing for monogenic disorders (PGT-M) is offered to patients at risk for transferring an embryo affected by an inheritable disease. There is a paucity of data investigating the relationship between parity in patients without an infertility diagnosis who undergo in vitro fertilization (IVF) with PGT-M.1 The objective of this study is to evaluate patients with and without a history of live birth undergoing initial synthetic single euploid embryo transfer (SEET) with genetically tested embryos for monogenic disorders
EXPANDING USE OF PREIMPLANTATION GENETIC TESTING FOR MONOGENIC DISORDERS (PGT-M) AMONG CARRIER COUPLES FOR CYSTIC FIBROSIS (CF)
Juliana Lindberg BA 1, Nirali Shah Jain M.D. 2, Andria G. Besser M.S. 2, Jennifer K. Blakemore MD, MSC 2
doi : 10.1016/j.fertnstert.2024.07.188
Volume 122, Issue 4, Supplement, October 2024, Page e44
Increased awareness and utilization of genetic carrier screening has yielded improved identification of CF carrier couples. As carrier screening of the CFTR gene has transitioned from targeted genotyping of common variants to full gene sequencing and copy number analysis, the spectrum of variants identified has evolved. Our objective was to explore the population of patients who pursued PGT-M for CF and the variants tested.
RE-BIOPSY OF BLASTOCYSTS WITH SEGMENTAL ANEUPLOIDY AFTER PGT-A: CLINICAL BENEFITS AND CONSIDERATIONS
Rina Abramov MSc 1, Mitko Madjunkov M.D. 1, Maya Sharon-Weiner MD 2, Clifford Librach MD 1, Svetlana Madjunkova M.D., M.SC., PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.189
Volume 122, Issue 4, Supplement, October 2024, Pages e44-e45
Are there clinical benefits to performing a re-biopsy on blastocysts with segmental aneuploidy (SA) after PGT-A?
EVALUATING HUMAN BLASTOCYST MORPHOLOGY AND POLYGENIC DISEASE RISK SCORES
Jordan O'Donnell MSc 1, Erik Widen PhD 2, Jia Xu PhD 2, Charlene A. Alouf PhD HCLD MBA 3, Teodora Popa PhD 1, Nathan R. Treff PhD, HCLD 2, Mark Kristiansen PhD 4, Diego Marin PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.190
Volume 122, Issue 4, Supplement, October 2024, Page e45
Several studies demonstrate significant reduction in disease prevalence when choosing one of the two siblings with polygenic risk scores (genotyping data) compared to random selection. The expected translational benefit to IVF patients assumes that morphology-based sibling embryo selection is equivalent to random selection, relative to polygenic disease reduction. This study investigates, for the first time, a possible correlation between embryo morphology and polygenic risk scores (PRS)
LEVERAGING HIGH RESOLUTION SNP DATA IN THE PGT TRIO TO CONFIRM PARENTAGE IN AN EMBRYO TROPHECTODERM BIOPSY WITH ULTRA HIGH CONFIDENCE
Alexander Griffith B.S. 1, Christopher Weier PH.D. 2, Kedrick McKissock BS 3, Kate Brown Ph.D 2, Tony Gordon PHD 4
doi : 10.1016/j.fertnstert.2024.07.191
Volume 122, Issue 4, Supplement, October 2024, Page e45
Approaching half a million IVF cycles annually in the US alone, errors in the laboratory are virtually unavoidable, and when they lead to the birth of an unrelated child, the consequences are devastating for all parties involved. By leveraging parental genomic DNA (gDNA) alongside amplified DNA from embryo trophectoderm biopsies, samples can undergo processing through a standard PGT-A workflow to yield highly reliable single nucleotide polymorphism (SNP) data permitting confident confirmation of biparental inheritance. This study aims to assess the efficacy of an enhanced assay and bioinformatics algorithm to interrogate parental-embryo relatedness using genome-wide SNP data within the framework of PGT
A CONTEMPORARY ANALYSIS METHOD TO UNCOVER LOSS OF HETEROZYGOSITY: EMPLOYING PAIRED SINGLE NUCLEOTIDE VARIANT (SNV) AND COPY NUMBER VARIANT (CNV) DATA WITHIN CLINICAL PGT-A CASES
Kedrick McKissock BS 1, Alexander Griffith B.S. 2, Kate Brown Ph.D 3, Christopher Weier PH.D. 4
doi : 10.1016/j.fertnstert.2024.07.192
Volume 122, Issue 4, Supplement, October 2024, Pages e45-e46
Copy-Neutral Loss of Heterozygosity (CN-LOH) describes the genetic anomaly where both copies of a genomic segment present as allelic duplicates. This can result from de novo loss of one parental segment followed by monosomy rescue from the remaining template or by shared parental homozygosity, as in cases of consanguinity. CN-LOH negatively impacts developing embryos through imprinting disorders and the inactivation of tumor suppressor genes which can result in sporadic pregnancy loss or severe clinical phenotypes. CN-LOH is observed in approximately 0.5%-1% of live births but its occurrence in IVF embryos is difficult to detect. Most PGT-A platforms analyze CNV or SNV data independently and the resulting embryos appear to be either competent transferable euploids or aneuploids, respectively. This retrospective study highlights the utility of a parallel CNV+SNV PGT-A pipeline to detect CN-LOH in a cohort of embryo biopsies, a sample type largely unexplored in CN-LOH literature
DISPARITIES IN TIME TO ENDOMETRIOSIS DIAGNOSIS: A LARGE RESEARCH NETWORK STUDY
Marisa R. Imbroane BS 1, Hanna Kim MD 2, Tommaso Falcone M.D. 2, Elliott G. Richards MD, PhD 2
doi : 10.1016/j.fertnstert.2024.07.201
Volume 122, Issue 4, Supplement, October 2024, Page e46
To assess whether there are disparities in time to endometriosis diagnosis following presentation for pelvic pain between patients of different ages, races, ethnicities, and body-mass index (BMI) calculations
EVALUATING THE NEED FOR EMERGENCY CONTRACEPTION RESOURCES AT THE UNIVERSITY OF TEXAS AT AUSTIN
Frances Elizabeth Cates BA 1, Krishna C. Hariprasad BSA 2, Nikita Kakkad BA, BS 3, Niels Levy-Thiebaut BS, BA 4
doi : 10.1016/j.fertnstert.2024.07.202
Volume 122, Issue 4, Supplement, October 2024, Pages e46-e47
This project aimed to evaluate the need for accessible, low-cost emergency contraception (EC) resources at the University of Texas at Austin (UT Austin), to identify the most significant barriers to obtaining EC, to better understand students’ knowledge and perceptions of EC, and to assess the impact of Texas’s reproductive healthcare climate on students’ EC acquisition
THE IMPACT OF RELIGION ON DECISION MAKING OF INFERTILE COUPLES
Angelica Garcia Keeme-Sayre B.S., B.A. 1, Jordan G. Kassab M.S. 2, Amelia G. Oppenheimer B.S. 1, Jason B. Huang M.D. 1, Blair T. Stocks M.D. Ph.D. 1, Larry I. Lipshultz M.D. 1
doi : 10.1016/j.fertnstert.2024.07.203
Volume 122, Issue 4, Supplement, October 2024, Page e47
With ideas such as God’s command to “be fruitful and multiply” in both Jewish and Christian texts and the Vatican’s disapproval of the use of in vitro fertilization (IVF), religious identities of male-factor infertility patients may affect how patients engage in reproductive health care. The goal of this study is to assess the saliency of religious beliefs on the male-factor infertility patient.
OUTCOMES FROM A FELLOW AND RESIDENT-RUN, MONITORED OVULATION INDUCTION (OI) PROGRAM AT THE LARGEST SAFETY NET HOSPITAL IN NEW YORK CITY
Gillian Stein M.D. 1, Rachel Linfield B.A., M. Phil 1, Carlos M. Parra MD 2, Amelia G. Kelly MD 2, Emily Michelle Weidenbaum MD 3, Nirali Shah Jain M.D. 2, Jacquelyn Shaw M.D. 2, Sarah D. Cascante MD 4, Jennifer K. Blakemore MD, MSC 2
doi : 10.1016/j.fertnstert.2024.07.204
Volume 122, Issue 4, Supplement, October 2024, Page e47
Improving access to fertility care is essential, especially for low socioeconomic and minority groups. At a large urban public hospital, patients (pts) receive care through a fellow and resident-run reproductive endocrinology and infertility clinic, which supports a monitored ovulation induction (OI) program. Our objective was to evaluate OI pregnancy outcomes to describe the program’s efficacy and guide quality improvement
CHARACTERISTICS OF SPERM DONORS IN THE UNITED STATES
Rachel Passarelli MD 1, Sophie Kauderer MPH 2, John L. Pfail MD 1, Danielle Velez M.D. 2
doi : 10.1016/j.fertnstert.2024.07.205
Volume 122, Issue 4, Supplement, October 2024, Pages e47-e48
Families of diverse backgrounds can have difficulty finding sperm donors who match their race/ethnicity secondary to underrepresentation of minority men in the sperm donor population. We aim to understand current sperm donor demographics as a step to increase diversity in this arena.
THE ASSOCIATION OF IN VITRO FERTILIZATION WITH SEVERE MATERNAL MORBIDITY ACROSS MATERNAL AGE GROUPS
Sara EK. Phillips MD, MPH 1, Molly S. Kornfield MD 1, Bharti Garg MBBS, MPH 2, Caroline Braun MD 1, Aaron B. Caughey M.D., Ph.D. 1, Sacha A. Krieg M.D., PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.206
Volume 122, Issue 4, Supplement, October 2024, Page e48
To evaluate how the association of in vitro fertilization (IVF) and severe maternal morbidity (SMM) varies by maternal age.
THE USE OF VIRTUAL REALITY TECHNOLOGY PRIOR TO EMBRYO TRANSFER: A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL
Jak Ozsarfati MSc 1, Samantha Yee PhD, MSW, RSW 2, Michal Dviri MD 2, Anjila Roumia MD 2, Lilach Marom Haham MD 3, Andie Blankenstein BSc 2, Ayesha Noman BSc 4, Avishai Gasner BSc 2, Shruti Bhaskar Pathak BSc 1, Shivani Nirmalbhai Dhanani BSc 2, Katy Fatemeh Fatemeh Moosavi BSc 1, Karen B. Glass MD 2, Pratibhasri A. Sharma M.D., M.D., B.S. 5, Ari Y. Baratz M.D. 6, Clifford Librach MD 7
doi : 10.1016/j.fertnstert.2024.07.207
Volume 122, Issue 4, Supplement, October 2024, Pages e48-e49
The use of complementary therapies to reduce anxiety and improve IVF outcomes is increasing. Various interventions, such as acupuncture or herbal medicine, have been studied, but their efficacy remains uncertain. Virtual reality (VR) technology has been gaining attention over the past two decades, owing to evidence of its therapeutic potential for anxiety management and stress reduction. The objective of the study was to evaluate the effect of virtual reality (VR) exposure on improving clinical pregnancy rate (CPR) and lowering anxiety in patients undergoing frozen embryo transfer (FET).
SHORT AND LONG-TERM EFFECTS OF EXPERIMENTAL VARICOCELE
Aram Minas DVM 1 2, Dunia - Waked Ph.D. Student 3, Valter Luiz Maciel Jr. Ph.D. 4, Mika Alexia Miyazaki MSC 5, Mariana P. Antoniassi PhD 6, Raquel Guilharducci MSC 7, Mariana Matera Veras PhD 8, Ricardo P. Bertolla DVM, PhD, HCLD(ABB) 9
doi : 10.1016/j.fertnstert.2024.07.208
Volume 122, Issue 4, Supplement, October 2024, Page e49
Varicocele is associated to a progressive decrease in male fertile potential, but it has yet to be determined if duration of varicocele is associated to altered sperm functional quality. This experimental study was carried out to investigate the time-dependent effects of varicocele on spermatogenesis, sperm parameters, and sperm functional traits.
DOES TRIGGER TYPE MATTER? EXPLORING OOCYTE YIELD AND BLASTOCYST UTILIZATION BY TRIGGER TYPE
Joshua Ewy MD 1, Benjamin J. Peipert MD 2, Margaret A. Rush MD 2, Nathan C. Koelper MPH 3, Suleena K. Kalra MD, MSCE 2, Clarisa R. Gracia MD, MSCE 2
doi : 10.1016/j.fertnstert.2024.07.209
Volume 122, Issue 4, Supplement, October 2024, Pages e49-e50
Many programs routinely recommend co-administration of a small dose of hCG with GnRHa trigger despite limited outcome data. The objective of this study was to characterize differences in oocyte and embryo yield between ovarian stimulation cycles triggered with human gonadotropin (hCG) alone, gonadotropin releasing hormone agonist (GnRHa) alone, and hCG/GnRHa co-trigger.
MARKERS OF FEMALE ADIPOSITY AND LIVE BIRTH IN PATIENTS SEEKING INFERTILITY CARE
Iris TIENLYNN. Lee MD 1, Kurt T. Barnhart M.D., M.S.C.E. 2, Wei-Ting Hwang PhD 3, Stefanie Hinkle PhD 4, Enrique F. Schisterman PhD 5, James M. Hotaling M.D., M.S. 6, Pauline Mendola MS PhD 7, C Matthew Peterson MD 6, Ginny L. Ryan MA, MD 8, Ellen Caniglia ScD 4, Erica Johnstone M.D. 6, Sunni L. Mumford MS PhD 3
doi : 10.1016/j.fertnstert.2024.07.210
Volume 122, Issue 4, Supplement, October 2024, Page e50
Body mass index (BMI) is a commonly used proxy for adiposity and higher BMI is associated with lower fecundity. Randomized trials have not demonstrated a benefit to weight loss, however. It is possible that BMI is not the most appropriate marker of adiposity in studies on fertility, as data in other fields suggest alternative markers may be superior in predicting clinical outcomes. This study aimed to examine the association between multiple markers of adiposity and live birth among patients seeking infertility care.
EVALUATING THE IMPACT OF FROZEN PARTNER SPERM IN NON-DONOR INTRAUTERINE INSEMINATION CYCLES
Alexandra Huttler M.D. 1, Denis A. Vaughan MD 1, Nicholas Hillis B.A. 2, Daniel W. Duvall Jr. BA 2, Denny Sakkas PH.D. 1, Quetrell Heyward M.D., M.B.A. 1, Riwa Sabbagh M.D. 1, Alan S. Penzias M.D. 3
doi : 10.1016/j.fertnstert.2024.07.211
Volume 122, Issue 4, Supplement, October 2024, Pages e50-e51
To evaluate clinical pregnancy rates of fresh versus frozen partner sperm in non-donor intrauterine insemination (IUI) cycles
IMPACT OF INFERTILITY DIAGNOSIS ON PLOIDY RATE IN ADVANCED MATERNAL AGE
Alixandra L. Domney M.D., M.P.H., Nitasha Gupta M.D., Hillary Pearson M.D., Alexandra Peyser M.D., Christine Mullin M.D.
doi : 10.1016/j.fertnstert.2024.07.212
Volume 122, Issue 4, Supplement, October 2024, Page e51
To determine whether there is an association between infertility diagnosis and rate of embryo ploidy in patients with advanced maternal age (>35yo)
BLASTOCYST SEGMENTAL ANEUPLOIDY BREAKPOINTS ARE HIGHLY CORRELATED WITH HUMAN GENOME FRAGILE SITES
Elaine deQuadros DHSc, MSc 1, Jia Xu PhD 2, Nathan R. Treff PhD, HCLD 2, Diego Marin PH.D. 2, Arielle Freedman M.Sc. 3, Cristian Tom Milevski B.S. 4, Kathleen A. Miller DHSc 4
doi : 10.1016/j.fertnstert.2024.07.213
Volume 122, Issue 4, Supplement, October 2024, Page e51
Fragile sites represent specific loci characterized by inhibition of DNA synthesis when exposed to known inhibitors and are particularly sensitive to replication stress and instability. HumCFS, a manually curated database of human chromosomal fragile sites, has catalogued 125 such loci. This study aims to investigate whether segmental aneuploidy breakpoints identified in human embryos are more likely to be present within known fragile sites.
IL-22's DUAL NATURE: BALANCING PROTECTION AND RISK IN PREGNANCY AMID INFLAMMATORY CHALLENGES
Umida Ganieva PhD 1, Mahmood Bilal PhD 2, Amy Thees PhD 3, Joanne Y-H Kwak-Kim MD, MPH, FCRI 4, Svetlana Dambaeva PH.D. 5
doi : 10.1016/j.fertnstert.2024.07.214
Volume 122, Issue 4, Supplement, October 2024, Page e52
IL-22 plays a crucial role in immune responses, particularly in regulating inflammatory responses within mucosal tissues. The endometrial mucosa exhibits remarkable scar-free regeneration following disruptions in its integrity, a process intricately governed by tight and adherens junctions that modulate cell-cell interactions. Changes in these junctions may impair endometrial permeability and hinder the appropriate regeneration of the uterine mucosal lining, potentially contributing to pregnancy complications. Here, we investigated the potential of recombinant IL-22 (rIL-22) in preventing inflammation-triggered abortion.
DEFICIENCY OF DNA REPAIR IN HUMAN PREIMPLANTATION EMBRYOS REVEALED BY CRISPR-Cas9: IMPLICATIONS GENOME STABILITY, IN VITRO EMBRYO CULTURE, AND THE EFFICACY OF CLINICAL GENE EDITING
Dagan Wells B.SC., PH.D. 1, Marga Esbert PhD 2, Munuse C. Savash Ishanzadeh MSc 3, Shiny Titus 4, Jack Fagan MSc 3, Ayman Haj Ali MSc 5, Richard T. Scott Jr. M.D. 6, Nada Kubikova Ph.D. 7
doi : 10.1016/j.fertnstert.2024.07.215
Volume 122, Issue 4, Supplement, October 2024, Page e52
CRISPR-Cas9 is a genome editing (GE) method that creates double-stranded breaks in DNA (DSBs) at specified sites. Mutations near a DSB can potentially be removed if cells mend the break via homology-directed repair (HDR), rebuilding the damaged area using a DNA template that lacks the mutation. Clinical GE in human embryos is controversial due to safety and ethical concerns. However, intervention at this stage represents the only time when delivery of CRISPR to every cell of an individual can be guaranteed (via microinjection). Our understanding of how embryonic cells resolve DSBs is limited, precluding an adequate evaluation of CRISPR. This study aimed to accomplish the first comprehensive characterization of the response of human embryos to DSBs produced by CRISPR.
DISRUPTION OF METHYLATION REPROGRAMING IN EARLY EMBRYONIC TISSUE LINEAGES WITH PATERNAL AGING
Blair R. McCallie PH.D. 1, Michelle M. Denomme Tignanelli B.SC., PH.D. 2, Mary E. Haywood PhD 1, Caitlen E. Stobbe BS 1, William B. Schoolcraft M.D. 3, Mandy Katz-Jaffe PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.216
Volume 122, Issue 4, Supplement, October 2024, Pages e52-e53
It is well known that advanced paternal age (APA) at conception is associated with an increased risk of sperm de novo DNA variants that have significant downstream effects on birth outcomes and offspring health. The aim of this study was to examine the first two embryonic tissue lineages, inner cell mass (ICM) and trophectoderm (TE), for other early signs of molecular disruptions inherited through the sperm genome in association with APA.
GENERATION OF GENOTYPED ARTIFICIAL OOCYTES FROM ENDOMETRIAL STROMAL CELLS AND BONE MARROW MESENCHYMAL STEM CELLS
Shelun Tsai M.D. 1, Philip Xie B.SC. 2, Stephanie Cheung M.S. 2, Zev Rosenwaks M.D. 2, Gianpiero D. Palermo M.D., PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.217
Volume 122, Issue 4, Supplement, October 2024, Page e53
The challenge in neogametogenesis is retaining the individual’s genomic makeup. We aimed to generate female gametes from genotyped endometrial stromal cells (EmSCs) and bone marrow mesenchymal stem cells (BM-MSCs) via somatic cell haploidization.
REPRODUCTIVE POTENTIAL IS PRIMARILY DRIVEN BY THE MOLECULAR ACTIVITY OF THE FUTURE FETAL TISSUE LINEAGE
Mandy Katz-Jaffe PH.D. 1, Blair R. McCallie PH.D. 1, Mary E. Haywood PhD 1, Kalyn Trowbridge B.S. 2, William B. Schoolcraft M.D. 1, Michelle M. Denomme Tignanelli B.SC., PH.D. 3
doi : 10.1016/j.fertnstert.2024.07.218
Volume 122, Issue 4, Supplement, October 2024, Page e53
A significant decline in developmental competence is observed relative to the timing of blastocyst development. Indeed, day 7 euploid blastocysts have half the live birth potential of day 5 euploid blastocysts following transfer. Nevertheless, the underlying molecular mechanisms driving this slower rate of development and the influence this timing has on reproductive potential remain in question. The aim of this study was to investigate the transcriptome of equivalent-grade embryos in association with the timing of blastocyst development
UNITED STATES RACIAL/ETHNIC DISPARITIES IN PGT-A UTILIZATION: AN ANALYSIS OF 2014-2020 SART CORS DATABASE
Akailah T. Mason-Otey MD, MS, David B. Seifer M.D
doi : 10.1016/j.fertnstert.2024.07.219
Volume 122, Issue 4, Supplement, October 2024, Page e54
The use of preimplantation genetic testing for aneuploidy (PGT-A) allows for the selection of euploid embryos and has been thought to improve outcomes in ART, particularly in women ?35 y/o. Very little is known regarding PGT-A utilization among minorities in the United States (US). The objective of this study was to determine the trend of racial/ethnic utilization of PGT-A in the US.
A POPULATION-BASED STUDY OF THE CO-OCCURRENCE OF HYPOSPADIAS AND CONGENITAL HEART DEFECTS AMONG BOYS CONCEIVED WITH ASSISTEDÂ REPRODUCTIVEÂ TECHNOLOGY
Melissa A. Richard PhD 11, Barbara Luke ScD, MPH 2, Sarah C. Fisher PhD 3, Dayana Betancourt MPH 4, Mahsa M. Yazdy PhD 5, Nina E. Forestieri MPH 6, Ethan Wantman MBA 7, Valerie L. Baker M.D. 8, Michael Eisenberg M.D. 9, Mitana Purkayastha PhD 10, Alastair G. Sutcliffe MD, PhD 11, Philip J. Lupo PhD, MPH 1
doi : 10.1016/j.fertnstert.2024.07.220
Volume 122, Issue 4, Supplement, October 2024, Page e54
We previously reported a higher prevalence of major congenital heart defects (CHDs) among boys born with hypospadias in registry linkage studies of 3.7 million pregnancies in 11 US states. Simultaneously, in registry data linked to fertility parameters, we observed excess risk for isolated hypospadias and CHD with conception by assisted reproductive technology (ART). We therefore sought to evaluate the association of co-occurring hypospadias and CHDs with method of conception.
THE RISK OF BIRTH DEFECTS IDENTIFIED DURING THE FIRST YEAR OF LIFE ASSOCIATED WITH PREIMPLANTATION TESTING AMONG CHILDREN CONCEIVED WITH IN VITRO FERTILIZATION (IVF) AND FROZEN EMBRYO TRANSFER
Katherine E. Cameron M.D. 1, Barbara Luke ScD, MPH 2, Mengmeng Li MSPH MBBS 3, Philip J. Lupo PhD, MPH 4, Alastair G. Sutcliffe MD, PhD 5, Mark P.D. Dow PH.D. 6, Valerie L. Baker M.D. 7
doi : 10.1016/j.fertnstert.2024.07.221
Volume 122, Issue 4, Supplement, October 2024, Pages e54-e55
To evaluate the association of trophectoderm biopsy and the risk of major birth defects in in vitro fertilization (IVF) conceptions with frozen embryo transfer.
NEONATAL OUTCOMES WORSEN WITH INCREASING BODY MASS INDEX: AN ANALYSIS OF 37,081 EUPLOID FROZEN EMBRYO TRANSFERS FROM THE SART CORS DATABASE
Sabrine Bensouda MD 1, Jennifer B. Bakkensen MD 2, Christina E. Boots M.D., MSCI 3
doi : 10.1016/j.fertnstert.2024.07.222
Volume 122, Issue 4, Supplement, October 2024, Page e55
While prior studies demonstrated that increasing body mass index (BMI) was associated with increased miscarriage and decreased live birth rates after euploid frozen embryo transfer (FET), this association was attenuated among patients with a sole diagnosis of male factor infertility. Here, we aim to evaluate the association of BMI with neonatal outcomes after euploid FET.
NEIGHBORHOOD DISADVANTAGE AND RACE ARE ASSOCIATED WITH DECISIONS REGARDING PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A)
Olamide O. Akin-Olugbade MD 1, Allison S. Komorowski M.D. 2, Jessica Almgren-Bell BA 3, Katherine Roberts BA 4, Riley Bonaccorsi BA, MA 5, Emily S. Jungheim M.D., M.S. 6
doi : 10.1016/j.fertnstert.2024.07.223
Volume 122, Issue 4, Supplement, October 2024, Pages e55-e56
To explore whether neighborhood disadvantage as measured by area deprivation index (ADI), and race were associated with decisions to pursue in-vitro fertilization (IVF) with a fresh, untested embryo transfer versus proceeding with pre-implantation genetic testing for aneuploidy (PGT-A) in a large cohort of socioeconomically diverse patients. ADI incorporates various socioeconomic indicators from US Census Data to provide a relative percentile of disadvantage on a nationwide level, with higher percentiles representing increased disadvantage.
RACIAL DISPARITIES IN ART OUTCOMES IN THE SOCIETY OF ASSISTED REPRODUCTIVE TECHNOLOGY (SART CORS) DATABASE: 2014-2021
Michelle H. Vu M.D. 1, Michael Chen PhD 2, Erin L. Scott M.D., PH.D., H.C.L.D. 3, Snigdha Alur-Gupta M.D. 4
doi : 10.1016/j.fertnstert.2024.07.224
Volume 122, Issue 4, Supplement, October 2024, Page e56
Asian American infertility is a particularly understudied area of research despite being one of the fastest growing racial groups in the United States. The Society of Assisted Reproductive Technology (SART CORS) database was used to evaluate racial disparities in ART treatment outcomes, with a focus on Asian women.
MORE ISN’T ALWAYS BETTER: A SART CORS ANALYSIS OF SURPLUS CRYOPRESERVED BLASTOCYSTS IN FRESH DONOR OOCYTE CYCLES
doi : 10.1016/j.fertnstert.2024.07.225
Volume 122, Issue 4, Supplement, October 2024, Pages e56-e57
To determine the number of fresh donor oocytes to fertilize to minimize supernumerary blastocysts while preserving live birth rates.
OPTIMIZING THE NUMBER OF FROZEN DONOR OOCYTES TO FERTILIZE WHILE MINIMIZING SUPERNUMERARY EMBRYOS: A SART CORS ANALYSIS
Shelun Tsai M.D. 1, Xiaoyue Ma M.Sc. 2, Samantha Spring M.D. 3, Steven D. Spandorfer M.D. 1
doi : 10.1016/j.fertnstert.2024.07.226
Volume 122, Issue 4, Supplement, October 2024, Page e57
To determine the optimal number of frozen donor oocytes to thaw and fertilize to achieve one live birth while minimizing supernumerary embryos.
UNDERSTANDING PEDIATRIC FERTILITY PRESERVATION IN THE UNITED STATES
Isabelle C. Band BA 1, Jacqueline Slobin MD 1, Jiwoo Park BA 1, Kerry S.J. Flannagan PhD 2, Lucy Greenwald BS 1, Bethany Dubois B.A. 1, Victoria Kirilov Lazarov MD 1, Katrina S. Nietsch MS 1, Jiarui Wang M.S. 2, Joseph A. Lee BA 3, Phillip A. Romanski M.D., M.SC. 3, Michael Vance Homer M.D. 4, Luis R. Hoyos M.D. 5, Meike L. Uhler M.D. 6, Kathleen Devine MD 2, Alan B. Copperman M.D. 3, Samantha Lauren Estevez M.D. 1
doi : 10.1016/j.fertnstert.2024.07.228
Volume 122, Issue 4, Supplement, October 2024, Pages e57-e58
The American Society for Reproductive Medicine and American Academy of Pediatrics advocate for fertility preservation (FP) counseling and referrals for patients with fertility-threatening conditions or who require gonadotoxic therapy. Inability to achieve biological parenthood may cause psychological stress later in life.1 FP increases potential to eventually conceive biologically related children. Few studies have evaluated characteristics of pediatric patients who pursue FP. This study assessed FP consultation trends among pediatric patients over a 20-year period
CAUTION IN THE USE OF ANTI-MULLERIAN HORMONE (AMH) IN COUNSELING YOUNGER PATIENTS UNDERGOING OOCYTE CRYOPRESERVATION (OC)
Evelyn Minis MD 1, Victoria S. Jiang M.D. 1, Victoria W. Fitz M.D., M.S. 2, Kaitlyn E. James PhD 3, Shruthi Mahalingaiah M.D., M.S. 4
doi : 10.1016/j.fertnstert.2024.07.229
Volume 122, Issue 4, Supplement, October 2024, Page e58
OC use has risen significantly over the past years. There are increasing reports of regret in patients undergoing elective OC in the literature and mainstream media. AMH is a valuable measure of ovarian reserve and is used to counsel patients on ovarian response. However, oocyte yield does not always match the expected response, based on AMH. The aim of this study is to assess the effect of AMH on overall oocyte and M2 yield across different age groups of patients undergoing OC.
PRELIMINARY RESULTS ON THE EFFECTS OF PRP ON ASTHENOSPERMIC SEMEN SAMPLES
Adriana Bos-Mikich PhD 1, Gabriella Mamede Andrade PhD 2, Norma P. Oliveira MSc 2, Giovanna Gonçalves BSc 2, Carina Saviello BSc 3, Fernanda I. Iglesias BSc 4, Nilo Frantz M.D. 2
doi : 10.1016/j.fertnstert.2024.07.230
Volume 122, Issue 4, Supplement, October 2024, Page e58
Men diagnosed with cancer may already present poor semen quality, and gonadotoxic treatment results in an additional reduction in sperm quality. Many patients may need to use ART to fulfill their desire to achieve a healthy live birth. IUI would be a cost effective alternative for these patients. The study aimed to access the effect of platelet rich plasm (PRP) on sperm motility.
THE IMPACT OF STATE INSURANCE MANDATES ON FERTILITY PRESERVATION ACCESS
Joshua M. Morris M.D., M.A. 1, Eliana Fine MD 2
doi : 10.1016/j.fertnstert.2024.07.231
Volume 122, Issue 4, Supplement, October 2024, Pages e58-e59
To assess the impact of state insurance mandates that include fertility preservation (FP) coverage for iatrogenic infertility enacted between 2017-2020 on FP utilization rates using aggregated data from the Center for Disease Control (CDC) from 2016 and 2021
EFFECT OF PROLONGED OOCYTE CRYOPRESERVATION ON FERTILIZATION AND PREGNANCY OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS
Amanda Kauffman BSc 1, Dalia Karol M.D. 2, Claire Jones B.SC., M.D. 3, Qixuan Li MSc 4, Ella Huszti PhD 5, Jennia Michaeli M.D. 6
doi : 10.1016/j.fertnstert.2024.07.232
Volume 122, Issue 4, Supplement, October 2024, Page e59
To elucidate the effect of duration of oocyte cryopreservation on cryosurvival, embryological, and pregnancy outcomes
RAPAMYCIN IMPROVES OOCYTE QUALITY BY PROMOTING METABOLIC AND MITOPHAGY ACTIVITIES IN MICE AND HUMAN GRANULOSA CELLS
Asrafun Nahar PH.D. 1, Hossein Yazdkhasti PhD 2, Zahra Rajabi PhD 2, Rebecca Holmes D.PHIL., H.C.L.D 3, William B. Schoolcraft MD 4, Ye Yuan PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.233
Volume 122, Issue 4, Supplement, October 2024, Pages e59-e60
Supplementation of rapamycin (Rapa) during in vitro maturation (IVM) has been shown to improve oocyte quality. Here, we aimed to elucidate the mechanisms of how Rapa affects signaling pathways in mice and human granulosa cells to promote oocyte quality.
TOO MUCH OF A GOOD THING? ASSESSING THE OPTIMAL NUMBER OF OOCYTES TO THAW TO PREDICT THE LIKELIHOOD DEVELOPING TWO OR MORE BLASTOCYSTS
Emily Auran Clarke M.D. 1, Carlos Hernandez-Nieto MD 2, Michelle J. Bayefsky MD 1, Morgan Baird MPH 2, Richard E. Slifkin M.S. 2, Joseph A. Lee BA 2, Christine Briton-Jones PhD 2, Alan B. Copperman M.D. 2
doi : 10.1016/j.fertnstert.2024.07.234
Volume 122, Issue 4, Supplement, October 2024, Page e60
As utilization of planned oocyte cryopreservation (OC) rises, patients are more frequently returning to thaw their oocytes with the goal of family building. Large oocyte thaws can create burdens to laboratory workflow, especially when robust utilization of thawed oocytes requires intracytoplasmic sperm injection, often combined with embryo biopsy for preimplantation genetic testing for aneuploidy. Patient benefit of thawing all available oocytes versus gradually thawing a smaller number from a large cohort of frozen tissue remains uncertain. Clarifying this variability could prevent the creation of supernumerary embryos and preserve unfertilized oocytes for reproductive autonomy. Therefore, it is paramount to calculate the optimal number of oocyte thaws to maximize the likelihood of blastocyst formation. This study analyzes the dynamic of an optimal threshold of oocyte thaws to yield two or more blastocysts.
WHAT TO EXPECT FROM YOUR FROZEN EGGS? CUMULATIVE LIVE BIRTH RATES (CLBRS) BY AGE AT PLANNED OOCYTE CRYORPRESERVATION (OC) AND NUMBER OF METAPHASE II OOCYTES (M2S) THAWED
Carlos M. Parra MD, Amelia G. Kelly MD, Jennifer K. Blakemore MD, MSC, Shannon DeVore MD, Alan Berkeley MD, Brooke Wertz MD, MPH, Caroline McCaffrey PHD, HCLD, Jamie A. Grifo MD, PHD, Sarah D. Cascante MD
doi : 10.1016/j.fertnstert.2024.07.235
Volume 122, Issue 4, Supplement, October 2024, Pages e60-e61
As more patients (pts) return after planned OC, we learn about the reproductive potential of cryopreserved autologous oocytes (AOs). This study assessed CLBRs by age at OC and number of M2s thawed
INVESTIGATING SOCIAL FACTORS CONTRIBUTING TO THE LACK OF DIVERSITY AMONG SPERM DONORS IN THE UNITED STATES
Olivia G. Anderson BS 1, Michaela A. Taylor MS 2, Hetanshi Naik PhD, MS, CGC 3, Lauren Isley MS, CGC 4, Katie Lee Hornberger B.S., M.SC. 5
doi : 10.1016/j.fertnstert.2024.07.237
Volume 122, Issue 4, Supplement, October 2024, Page e61
There is a lack of racial and ethnic diversity among sperm donors in the United States, which presents challenges for recipients seeking donors who share their own ethnicity and physical characteristics. This lack of diversity persists despite recruiting efforts from sperm banks. This study aimed to identify social and cultural factors which may contribute to this phenomenon
COMPARING FAMILY PLANNING DESIRES AND BARRIERS BETWEEN GAY AND LESBIAN MILITARY SERVICE MEMBERS
David Boedeker D.O., MHA 1, Kiley Hunkler M.D., MSt, MSc 2 3, Peter G. Lindner MD 1, Keeley Phillips BS 4, Micah J. Hill DO 5, Torie C. Plowden M.D., M.P.H 6, Rebekah Cole PhD 4
doi : 10.1016/j.fertnstert.2024.07.238
Volume 122, Issue 4, Supplement, October 2024, Page e61
To investigate family planning amongst military service members identifying as LGBTQ+
COMPARING FAMILY-BUILDING DESIRES AMONG TRANSGENDER AND CISGENDER GAY, BISEXUAL, AND LESBIAN MILITARY SERVICE MEMBERS
David Boedeker D.O., MHA 1, Kiley Hunkler M.D., MSt, MSc 2, Michael Pacheco BS 3, Michael Zamani MS 1, Micah J. Hill DO 4, Jacqueline Y. Kikuchi MD 1
doi : 10.1016/j.fertnstert.2024.07.239
Volume 122, Issue 4, Supplement, October 2024, Pages e61-e62
Barriers to infertility services among lesbian, gay, bisexual, transgender, nonbinary, and queer (LGBTQ+) identifying individuals are well documented, but little is known about how these individuals pursue fertility services in the United States Military Health System, which is a universal healthcare setting. We sought to compare family-building desires and barriers to care between transgender and gender-diverse (TGD) military service members and lesbian, gay, or bisexual (LGB) cisgender service members in a universal healthcare setting
LIVE BIRTH RATES IN SAME-SEX FEMALE COUPLES ARE SIMILAR BETWEEN CO-IN-VITRO FERTILIZATION (CO-IVF) AND AUTOLOGOUS IVF
Bethany Dubois B.A. 1, Tamar Alkon-Meadows M.D. 2, Dmitry Gounko B.S., M.A. 2, Alexandra Mills MD 1, Katrina S. Nietsch MS 1, Isabelle C. Band BA 1, Nicole Parkas BS 1, Joseph A. Lee BA 2, Stephanie Brownridge M.D. 2, Alan B. Copperman M.D. 2, Samantha Lauren Estevez M.D. 3
doi : 10.1016/j.fertnstert.2024.07.240
Volume 122, Issue 4, Supplement, October 2024, Page e62
Same-sex female couples (SSFC) pursuing family building via in-vitro fertilization (IVF) can select between autologous IVF, where a single partner provides oocytes and carries out gestation, or Co-IVF, where one partner donates an oocyte and the other partner receives the embryo at transfer.1 Important factors for this decision include medical history of both partners, desire for shared biologic contribution, cost, and pregnancy success rates.2 This study aims to compare live birth rates in SSFC undergoing Co-IVF to autologous IVF cycles
DISPARITIES IN FERTILITY PRESERVATION COUNSELING AND REFERRALS FOR PATIENTS SEEKING GENDER-AFFIRMING CARE
Gabriella Ficerai-Garland B.A. 1, Alexandra A. Szczupak M.D. 2, Amanda Colvin Ph.D 3, Jennifer Anglin BA 4, Rachel E. Neelley B.A. 1, Julie M. Rios M.D. 2, Kyle E. Orwig PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.241
Volume 122, Issue 4, Supplement, October 2024, Pages e62-e63
Counseling and referral for fertility preservation (FP) consultation are essential in providing patient-centered care for individuals facing possible fertility-limiting treatments. Gender diverse patients may receive less counseling prior to gender affirming treatments (GAT) that could affect fertility. This study explores the FP experiences of patients with gender dysphoria (GD) undergoing GAT compared to patients receiving treatment for cancer or another serious illness (CSI
LOW INCOME AFRICAN AMERICAN WOMEN WITH A HISTORY OF RECURRENT PREGNANCY LOSS ARE AT INCREASED RISK OF HYPERTENSIVE DISORDERS OF PREGNANCY AND POOR BIRTH OUTCOMES THAN RACE AND INCOME MATCHED PEERS
doi : 10.1016/j.fertnstert.2024.07.242
Volume 122, Issue 4, Supplement, October 2024, Page e63
Recurrent pregnancy loss (RPL) affects 2-5% of patients and pregnancy induced hypertensive disorders (PIH)disorders are a major cause of maternal morbidity. However, both conditions are poorly understood, plagued by racial disparities, and associated with future cardiovascular disease. The objective of this study is to assess the risk of PIH in low-income Black women with a history of RPL, a group that has historically been underrepresented in prior studies
LAG TIME BETWEEN SCHEDULING DATE AND APPOINTMENT DATE FOR INITIAL INFERTILITY EVALUATION: DOES PREFERRED PRIMARY LANGUAGE PLAY A ROLE?
Blakeley Schiffman M.D. 1, Sarika Arora B.A. 2, Alixandra L. Domney M.D., M.P.H. 1, Hillary Pearson M.D. 1, Randi H. Goldman B.S., M.D. 1
doi : 10.1016/j.fertnstert.2024.07.243
Volume 122, Issue 4, Supplement, October 2024, Pages e63-e64
Navigating the American healthcare system presents many challenges for non-English speaking patients despite the lack of an official language of the United States. Longer lag time, as defined by the time interval between scheduling date and appointment date, is a challenge that may negatively impact timely diagnosis and treatment. We aimed to identify differences in lag time between preferred English vs. non-English speakers.
BARRIERS TO FERTILITY PRESERVATION TREATMENT PRIOR TO GENDER-AFFIRMING BOTTOM SURGERY WITHIN THE MILITARY HEALTH SYSTEM
David Boedeker D.O., MHA, Kiley Hunkler M.D., MSt, MSc, Elisabeth Kan BA, Jacqueline Y. Kikuchi MD
doi : 10.1016/j.fertnstert.2024.07.244
Volume 122, Issue 4, Supplement, October 2024, Page e64
To evaluate barriers transgender and gender diverse (TGD) patients face when pursuing fertility preservation prior to gender-affirming bottom surgery within the military health system
SURGICAL AND MEDICAL MANAGEMENT OF EARLY PREGNANCY FAILURE (EPF): REPRODUCTIVE POTENTIAL IN SUBSEQUENT SINGLE EUPLOID EMBRYO TRANSFER (SEET) CYCLES
Emily Auran Clarke M.D. 1, Sarah C. Roger M.D. 1, Raina Kishan MD 1, Morgan Baird MPH 2, Joseph A. Lee BA 2, Eric Flisser M.D. 2, Tanmoy Mukherjee M.D. 2, Alan B. Copperman M.D. 2
doi : 10.1016/j.fertnstert.2024.07.246
Volume 122, Issue 4, Supplement, October 2024, Page e64
Treatment options for EPF include dilation and curettage (D&C), misoprostol, or expectant management, with both surgical and medical options accepted in patients undergoing in vitro fertilization (IVF). It is known that endometrial thickness (ETh) <7mm is associated with poor IVF outcomes (1). However, current data on ETh after D&C vs misoprostol conflicts (2). Few studies on EPF management have evaluated reproductive potential in subsequent IVF cycles. This study compares subsequent SEET outcomes in patients who underwent management of EPF.
IMPACT OF GONADOTROPIN SELECTION ON RISK OF OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN PREDICTED HIGH RESPONDERS UNDERGOING OVARIAN STIMULATION: A MEGASET HR TRIAL ANALYSIS
Russell A. Foulk M.D. 1, Cristin C. Slater M.D. 2, Vishvanath Karande M.D. 3, Lindsay Kelly PhD 4, Eric D. Foster PhD 4, Sasmira I. Lalwani M.D. 4, Gaurang S. Daftary M.D. 4, Patrick W. Heiser PhD 4
doi : 10.1016/j.fertnstert.2024.07.247
Volume 122, Issue 4, Supplement, October 2024, Pages e64-e65
To evaluate risk of developing OHSS with use of highly purified human menotropin (HP-hMG) versus recombinant follicle stimulating hormone (rFSH) for ovarian stimulation in predicted high responder patients
BREAKING THE ICE: A DEEP DIVE INTO AGE-DEPENDENT EFFECTS OF ENDOMETRIAL PREPARATION PROTOCOLS IN FROZEN EMBRYO TRANSFER OUTCOMES FROM A LARGE MONOCENTRIC COHORT (4662 CYCLES)
Nathalie Massin M.D. 1, Frida Entezami MD 2
doi : 10.1016/j.fertnstert.2024.07.248
Volume 122, Issue 4, Supplement, October 2024, Page e65
The objective of the study was to compare reproductive outcomes in Frozen Embryo Transfer (FET) in two distinct endometrial preparation protocols: the artificial cycle (AC) involving sequential estrogen/progesterone, and the protocol incorporating a Corpus Luteum (mNC), namely, natural, modified natural, or stimulated cycles (with or without gonadotrophins, HCG triggering, and progesterone luteal support). Current evidence indicates adverse outcomes, including reduced live birth rates, maternal-fetal risks (e.g., pre-eclampsia), and long-term neonatal health issues with AC.
THE IMPACT OF ENDOMETRIAL AND EMBRYO RELATED FACTORS ON CLINICAL OUTCOMES AND LIVE BIRTH IN PROGRAMMED AND MODIFIED NATURAL FET CYCLES WITH EUPLOID EMBRYO TRANSFERS
Cihan Halicigil H.C.L.D, PH.D. 1, Murat Basar Ph.D. 2, Olga Chaplia Ph.D. 1, Stephanie M. Nichols-Burns M.S., PH.D., HCLD 1
doi : 10.1016/j.fertnstert.2024.07.249
Volume 122, Issue 4, Supplement, October 2024, Page e65
To identify the influence of key patient and embryo related characteristics on clinical outcomes and live birth in modified natural and programmed frozen embryo transfers (FET)
OUTCOMES AFTER PROGRAMMED FROZEN EMBRYO TRANSFER FAILURE: DOES CHANGING THE PROTOCOL IMPROVE OUTCOMES?
Jennifer Chae-Kim M.D. 1, Kerry S.J. Flannagan PhD 2, Laura X. Zalles M.D. 3, Ariel Z. Benor M.D. 4, Kathleen Devine MD 2, Phillip A. Romanski M.D., M.SC. 5, Micah J. Hill DO 6, Benjamin S. Harris M.D., M.P.H 7
doi : 10.1016/j.fertnstert.2024.07.250
Volume 122, Issue 4, Supplement, October 2024, Page e66
For patients with a failed euploid programmed frozen embryo transfer (FET), it is unclear whether changing protocols for endometrial preparation is beneficial for pregnancy outcomes, in the setting of prior adequate response. We sought to compare outcomes for women who do not have a live birth (LB) after a programmed FET and undergo another programmed FET compared to those that undergo a change to natural FET protocol. We hypothesize that there is a higher LB rate among women who undergo a protocol switch to natural FET.
WHO BENEFITS MOST FROM A FREEZE-ALL EMBRYO TRANSFER STRATEGY? AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS (INFORM)
Rui Wang MD, PhD 1, Ling Shan Au MSc 2, Daimin Wei PhD 3, Richard S. Legro M.D. 4, Ze Wang PhD 3, Yun Sun MD 5, Keliang Wu M.D. 6, Lan N. Vuong MD, PhD 7, Pollyanna Hardy Msc 8, Anja Bisgaard Pinborg MD, PhD 9, Carlos Gomez MSc 10, Diana Valbuena Perilla MD, PHD 11, Christophe Blockeel MD, PhD 12, Samuel Santos-Ribeiro MD, PhD 13, Femke Mol M.D., PhD 14, Bruce S. Shapiro M.D., Ph.D., H.C.L.D. 15, Forest C. Garner M.S. 16, Rong Li M.D., PH.D. 17, Shimona Lai MBBS 2, David J. McLernon PhD 18…Abha Maheshwari MD, FRCOG 20
doi : 10.1016/j.fertnstert.2024.07.251
Volume 122, Issue 4, Supplement, October 2024, Page e66
To compare freeze-all and fresh embryo transfer strategies in patients undergoing IVF and to identify patient subgroups that are most likely to benefit from either strategy.
MODE OF DELIVERY IMPACTS SUBSEQUENT PREGNANCY ATTEMPTS IN PATIENTS RETURNING FOR SINGLE, EUPLOID FET USING THE SAME EMBRYO COHORT
Stephanie Willson MD 1, Haley G. Genovese M.D. 2, Paul A. Bergh M.D. 1
doi : 10.1016/j.fertnstert.2024.07.252
Volume 122, Issue 4, Supplement, October 2024, Pages e66-e67
The prevalence of cesarean section (CS) has been steadily increasing, and is expected to continue to increase over the next decade. Previous studies have demonstrated decreased live birth rates in women undergoing IVF with a history of a cesarean section compared to spontaneous delivery (SVD). However, these studies are limited in their assessment by possible confounders, such as interval change in the number and stage of embryos transferred, cycle type, ploidy status, and patient’s age between embryo transfers. By studying pregnancy attempts using the same embryo cohort as the initial successful pregnancy, the influence of these confounders can be mitigated. The objective of this study is to evaluate the impact of the mode of delivery of a first pregnancy on the pregnancy outcomes of subsequent single, euploid FET attempts from the same embryo cohort.
SUPPLEMENTAL ESTROGEN FOR ENDOMETRIAL THICKENING DOES NOT IMPROVE PREGNANCY RATES IN ORAL OVULATION INDUCTION INTRAUTERINE INSEMINATION CYCLES
Florence Osei MD 1, Carrie Malcom MD, PhD 1, Kerry S.J. Flannagan PhD 2, Phillip A. Romanski M.D., M.SC. 3, Anthony N. Imudia M.D. 4
doi : 10.1016/j.fertnstert.2024.07.253
Volume 122, Issue 4, Supplement, October 2024, Page e67
To determine whether supplemental estrogen (E2) treatment during the follicular phase of intrauterine insemination (IUI) cycles using letrozole and/or clomiphene for ovulation induction when the endometrial thickness is <7mm improves pregnancy outcomes
ROUTINE HYPERPROLACTINEMIA SCREENING IN THE INITIAL FERTILITY EVALUATION: A RETROSPECTIVE ANALYSIS OF INDICATED AND UNINDICATED TESTING
Blakeley Schiffman M.D., Amy Ng M.D., Alexandra Peyser M.D., Lauren Ursillo M.D., Randi H. Goldman B.S., M.D.
doi : 10.1016/j.fertnstert.2024.07.254
Volume 122, Issue 4, Supplement, October 2024, Pages e67-e68
Prolactin (PRL) testing is not recommended as part of the initial fertility evaluation unless indicated by a history of amenorrhea, oligomenorrhea or galactorrhea, according to the American Society of Reproductive Medicine. Despite this recommendation, serum PRL is often routinely tested even if screening criteria are not met. We aimed to identify the proportion of indicated and nonindicated PRL screening amongst those with elevated serum PRL during the initial fertility workup, along with subsequent treatment interventions.
RANDOMIZED CONTROLLED TRIAL OF HOME SEMEN TESTING FOR PROSPECTIVE FATHERS: SEMEN ANALYSIS RESULTS AND 3-MONTH FOLLOW UP
Daniel R. Greenberg M.D. 1, Lydia Landrum BS 2, Lisa Nehring MS 3, Sai Kaushik Shankar Ramesh Kumar MS 4, Evan J. Panken MD 2, Kian Asanad MD 5, Robert E. Brannigan M.D. 2, Joshua A. Halpern M.D., M.S. 5
doi : 10.1016/j.fertnstert.2024.07.255
Volume 122, Issue 4, Supplement, October 2024, Page e68
The path to family building can cause significant distress and anxiety for prospective fathers. We aimed to determine if home semen testing (HST) for men in the early stages of family building can improve fertility-related quality of life
ANALYZING ENDOMETRIOSIS-RELATED INFERTILITY CONTENT ON TIKTOK: WHO IS SAYING WHAT?
Hajer Naveed BA 1, Donessa Colley BS 1, Tomiris Atazhanova MD, MSc 2, Susan Khalil MD 1, Mary Ellen Pavone MD, MSc 2
doi : 10.1016/j.fertnstert.2024.07.256
Volume 122, Issue 4, Supplement, October 2024, Page e68
Given TikTok’s surging popularity, the platform has become an important space for medical discourse. Patients increasingly turn to social media for health care insights and medical advice, especially within the population impacted by endometriosis (1). Considering this, the terrain of endometriosis-related content on TikTok remains relatively under-explored. This study aims to analyze the content on TikTok specific to endometriosis-related infertility
HOW DOES A SHORT-TERM DROP IN ANTI-MULLERIAN HORMONE (AMH) IMPACT IN VITRO FERTILIZATION (IVF) OUTCOMES AMONG NORMAL RESPONDERS?
Amanda D. Kadesh M.D., M.S. 1, Haley G. Genovese M.D. 2, Stephanie Willson MD 2, Emre Seli M.D. 2, Marie D. Werner B.A., H.C.L.D, M.D. 2
doi : 10.1016/j.fertnstert.2024.07.257
Volume 122, Issue 4, Supplement, October 2024, Pages e68-e69
AMH is known to be a chief predictor of ovarian response to stimulation. However, it is unknown how a short-term decrease in AMH impacts treatment outcomes among normal responders
MULTIPLE GESTATION PREGNANCY RATES AFTER ULTRASOUND MONITORED VS OVULATION PREDICTOR KIT MONITORED OVULATION STIMULATION-INTRAUTERINE INSEMINATION CYCLES
Elizabeth L. Wolfe M.D. 1, Jennifer D. Peck PhD 2, Blake Evans D.O. 3
doi : 10.1016/j.fertnstert.2024.07.258
Volume 122, Issue 4, Supplement, October 2024, Page e69
Live birth rates have been shown to be comparable between ovarian stimulation - intrauterine insemination (OS-IUI) cycles that use either an office-based ultrasound monitored protocol and cycles that are monitored with home-based patient administered ovulation predictor kits (OPKs). It is unclear if there is a difference in multiple gestation pregnancy rates between these two protocols, given that in OPK cycles, over-response to medication and subsequent ovulation of multiple dominant follicles is unable to be assessed. This study sought to evaluate the hypothesis that the risk of a multiple gestation pregnancy is higher in OPK cycles compared to ultrasound monitored cycles
MIG-6 LOSS OF ECTOPIC LESIONS CAUSES IMPLANTATION FAILURE IN ENDOMETRIOSIS
Hossein Hosseinirad DVM-PhD 1, Dinh Nam Nam Tran DVM-PhD 2, Monica Jeong BEd 3, Tae Hoon Kim Ph.D. 3, Jae-Wook Jeong PH.D. 1
doi : 10.1016/j.fertnstert.2024.07.259
Volume 122, Issue 4, Supplement, October 2024, Page e69
Despite the clinically recognized association between endometriosis and infertility, the molecular mechanisms of endometriosis-related infertility have not well understood. The mitogen-inducible gene 6 (MIG-6) which acts as a progesterone-regulated gene is downregulated in the eutopic endometrium of infertile women with endometriosis. In this study, we assess the effect of endometriosis with MIG-6 deficiency on fertility and implantation using a mouse endometriosis model.
ASSOCIATION OF ELEVATED MIDCYCLE LUTEINIZING HORMONE AND PREGNANCY OUTCOMES IN PROGRAMMED FROZEN EMBRYO TRANSFER CYCLES
Ashley Ulker MD 1, Jennifer D. Peck PhD 2, Ashley Moriarty RN, BSN 1, LaTasha B. Craig M.D. 1
doi : 10.1016/j.fertnstert.2024.07.260
Volume 122, Issue 4, Supplement, October 2024, Page e70
The use of programmed frozen embryo transfer (FET) cycles has increased substantially in recent years, so the investigation of methods to optimize outcomes are warranted. Luteinizing hormone (LH) level is not always part of routine testing during FET cycles, but prior investigations on the impact of midcycle LH levels on pregnancy outcomes in programmed FET cycles are mixed. We aim to study the impact of elevated midcycle LH levels on pregnancy outcomes in programmed FET cycles that utilize intramuscular progesterone.
PRESENCE OF CD138 (+) PLASMA CELLS IN THE ENDOMETRIUM DOES NOT CORRELATE WITH HISTORY OF PRIOR IMPLANTATION FAILURE, ENDOMETRIAL BCL6 LEVELS OR ENDOMETRIAL RECEPTIVITY TESTING
Bahar D. Yilmaz M.D., Meagan Chan DNP, Kaia M. Schwartz M.D., Hakan Cakmak MD, Marcelle I. Cedars MD, David Huang MD
doi : 10.1016/j.fertnstert.2024.07.261
Volume 122, Issue 4, Supplement, October 2024, Page e70
Our study aims to assess if chronic endometritis (CE), determined by the presence of CD138 (+) plasma cell clusters, is more prevalent in patients with prior failed implantation history compared to those without, and to assess if presence of CE correlates with abnormal outcomes in other concurrent endometrial evaluations. This investigation is critical given the unclear impact of CE on reproductive outcomes, and the ongoing debate over its diagnostic criteria and treatment in reproductive medicine
EPITHELIAL-TO-MESENCHYMAL TRANSITION INDUCTION BY HUMAN UMBILICAL CORD PLATELET-RICH PLASMA IN HUMAN ENDOMETRIAL ORGANOIDS: DIFFERENTIATION STATE MATTERS
Marcos Agustina-Hernández M.Sc. 1, Adolfo Rodríguez-Eguren M.Sc. 1, María Gómez-Álvarez M.Sc. 1, Clara Bueno-Fernandez PhD 2, Emilio Francés-Herrero PhD 1, Amparo Faus B.Sc. 1, Mónica Romeu MD, PhD 3, Amparo Galán PhD 4, Antonio Pellicer MD, PhD 5, Irene Cervello PhD 1
doi : 10.1016/j.fertnstert.2024.07.263
Volume 122, Issue 4, Supplement, October 2024, Pages e70-e71
Human endometrial organoids (hEOs) are revolutionizing cell culture models recapitulating the native tissue in the reproductive field. Previous in vitro studies treating undifferentiated hEOs with human umbilical cord platelet-rich plasma (hUC-PRP), a promising regenerative treatment, generated an apparent epithelial-to-mesenchymal transition (EMT). Based on these results, we aimed to investigate whether hUC-PRP also produced EMT in differentiated into secretory phase hEOs, which are closer to the native endometrium.
WITHDRAWN
doi : 10.1016/j.fertnstert.2024.07.264
Volume 122, Issue 4, Supplement, October 2024, Page e71
MULTI-OMICS ANALYSIS REVEALS TRANSLATIONAL LANDSCAPES AND REGULATIONS IN MOUSE AND HUMAN OOCYTE AGING
Jiana Huang M.M.
doi : 10.1016/j.fertnstert.2024.07.265
Volume 122, Issue 4, Supplement, October 2024, Page e71
Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal aging and ultimately lead to infertility. Transcriptional silencing makes translational control an urgent task during meiosis resumption in maternal aging. However, insights into aging-related translational characteristics and underlying mechanisms are limited. We aimed to investigate the precise translational landscapes and the functions of translational regulatory factors during oocyte aging by analyzing the single-cell translatome and transcriptome in GV-stage oocytes from young and aged female mice/humans. Additionally, the conservation and differences of oocyte aging between two species are investigated via integrated analysis of the translatomics and translational regulators alterations during oocyte aging from two species, which may help to provide specific intervention strategy of oocyte aging to two species.
OVARIAN SUPPORT CELL IN VITRO MATURATION RESULTS IN HEALTHY MURINE LIVE BIRTHS WITH NO EVIDENCE OF REPROTOXICOLOGY IN A MULTIGENERATIONAL STUDY
Maria Marchante PhD 1, Ferran Barrachina PhD 2, Enric Mestres PhD 3, Mònica Acacio MSc 3, Sabrina Piechota B.SC. 1, Nuno Costa Borges PhD 3, Christian Clark Kramme PhD 4
doi : 10.1016/j.fertnstert.2024.07.266
Volume 122, Issue 4, Supplement, October 2024, Pages e71-e72
Our group has developed an ovarian support cells (OSCs) platform derived from human induced pluripotent stem cells for in vitro maturation (IVM). The OSCs demonstrated robust human and murine in vitro oocyte maturation and an improved blastocyst formation rate compared to commercial IVM options (Piechota et al. 2023). However, the potential reproductive toxicity of OSCs on offspring remains unexplored. Therefore, this study aimed to evaluate the OSC's reproductive toxicity profile in a multigenerational murine study
ROLE AND MECHANISM OF NUCLEAR PORE PROTEIN NUP205 INVOLVED IN FOLLICLE DEVELOPMENT
Siying Cai M.S., Huiying Li Ph.D., Qiaojuan Mei Ph.D., Kexin Li M.S., Ling Zhang Ph.D., Huaibiao Li Ph.D., Wenpei Xiang Ph.D
doi : 10.1016/j.fertnstert.2024.07.267
Volume 122, Issue 4, Supplement, October 2024, Page e72
The decline in ovarian function caused by genetic, immunological and other factors is the main cause of fertility decline. Our group conducted a preliminary study of premature ovarian failure in six cases and found a possible association between NUP205 gene mutations and the occurrence of this condition. The aim of this study is to elucidate the role and mechanism of NUP205 protein in follicular development
THE EFFECTS OF THE ENDOCRINE-DISRUPTING CHEMICAL TRICLOSAN ON OVARIAN RESERVE AND FECUNDITY IN A MOUSE MODEL
Katie M. Baker M.D. 1, Kathryn J. Grive PhD 2
doi : 10.1016/j.fertnstert.2024.07.268
Volume 122, Issue 4, Supplement, October 2024, Page e72
Endocrine-disrupting chemicals (EDCs) are a diverse group of chemical compounds that mimic or block endogenous hormones leading to adverse health outcomes. Triclosan (TCS) is an anti-bacterial agent and known EDC that has been used in personal care and household products for decades. TCS exposure is widespread with nearly ¾ of females in the US having detectable urinary levels. TCS has been shown to impact female reproduction with decreased fecundity in those with the highest urinary concentrations. Despite this, very few studies have examined the effects of triclosan on female reproduction and its impact on the ovary.
THE ORIGIN OF MONOSOMY X IN THE HUMAN BLASTOCYST
Jia Xu PhD, Diego Marin PH.D., Nathan R. Treff PhD, HCLD
doi : 10.1016/j.fertnstert.2024.07.269
Volume 122, Issue 4, Supplement, October 2024, Pages e72-e73
Turner Syndrome is a genetic condition caused by loss of one of the sex chromosomes leaving only one X chromosome in the embryo (45,XO). This condition affects ?0.04% female newborns worldwide and has been heavily investigated at post-implantation stages of development. This study aims to investigate XO parental and cell division origins through the analysis of IVF derived blastocyst biopsies using preimplantation genetic testing (PGT)
EXPLORING THE MECHANISM OF ENDOMETRIAL MICRORNA REGULATION IN SUCCESSFUL IMPLANTATION
Chun-I. Lee M.D., Ph.D. 1, Pin-Yao Lin M.D., Ph.D. 1, Yu-Jen Lee Ph.D. 1, En-Hui Cheng Ph.D. 1, Tsung-Hsien Lee M.D., Ph.D. 2, Chi-Ying Lee M.S. 1, Ming-Jer Chen M.D., M.Sc. MCE 1, Eric Pok Yang Ph.D. 3, Maw-Sheng Lee M.D., Ph.D. 1
doi : 10.1016/j.fertnstert.2024.07.270
Volume 122, Issue 4, Supplement, October 2024, Page e73
The failure of embryo implantation represents a critical challenge in infertility treatment. Alongside the necessity for high-quality embryos and an optimal endometrial environment, effective communication between the two plays an important role in successful implantation. Extracellular vesicles (EVs), which contain proteins and microRNA, serve as carriers for carrying messages in the crosstalk process. MicroRNA has played a key role in the embryonic implantation process. Whether it is expressed in the embryo or endometrium, it can regulate the expression of its genes, or through extracellular vesicles form cross-talk and affect the expression of downstream genes, thereby promoting or inhibiting embryo implantation. This study aimed to understand which endometrial microRNAs may influence embryo implantation and to evaluate potential mechanisms using systems biology analysis.
SHARED GENOMIC SEGMENT ANALYSIS IN LARGE HIGH-RISK STILLBIRTH PEDIGREES IMPLICATES GENES IN INHERITED STILLBIRTH RISK
Tsegaselassie Workalemahu M.S., PH.D. 1, Michael J. Madsen MSTAT 2, Sarah Lopez MPH 3, Nathan R. Blue MD 1, Jessica Page MD 4, Aaron Quinlan PhD 5, Hilary Coon PhD 1, Lynn B. Jorde PhD 5, Nicola J. Camp PhD 5, Bob M. Silver MD 5
doi : 10.1016/j.fertnstert.2024.07.271
Volume 122, Issue 4, Supplement, October 2024, Pages e73-e74
Stillbirth is a common and devastating adverse pregnancy outcome. Though an etiology may be found in some stillbirth cases, 50% remain unexplained. Stillbirth has been shown to cluster in families and apart from infrequent aneuploidies, few underlying inherited genes in stillbirth cases are known. Our objective is to identify genetic contributors to stillbirth by utilizing a well-characterized family-based study.
FOLLICULAR FLUID LEVELS OF THE CHEMOKINE CCL2 CORRELATE WITH OOYCTE MATURATION RATES
Yamila Gamaleri Undergraduate Student 1, Delfina Ferman Undergraduate Student 1, Clara Corcuera Ibáñez Undergraduate Student 2, Diego Raffo PhD 1, Sabrina De Vincentiis M.S. 2, Jon D. Hennebold PH.D. 3, Santiago Brugo M.D. 2, Marina C. Peluffo Ph.D 1
doi : 10.1016/j.fertnstert.2024.07.272
Volume 122, Issue 4, Supplement, October 2024, Page e74
To determine if IVF outcomes are associated with chemokine C-C Motif Ligand 2 (CCL2) follicular fluid (FF) levels and cumulus cell CCL2 synthesis from patients undergoing infertility treatment
UNRAVELING THE ROLE OF SIRTUIN 7 IN REPRODUCTIVE AGING
Karen A. Schindler PH.D. 1, Mayra Romero BS 2, Berta Vazquez Phd 3, Anna Guitart MSc 4, Alejandro Vaquero PhD 5
doi : 10.1016/j.fertnstert.2024.07.273
Volume 122, Issue 4, Supplement, October 2024, Page e74
Reproductive aging has profound impacts on women’s health, affecting hormone production, fertility, quality of life and longevity. The purpose of this study was to determine the role of anti-aging gene Sirt7 in egg quality compared to sperm
ATTITUDES TOWARDS SPERM DONATION IN BLACK CISGENDER MEN
Kameron L. King BA 1, Dwayne Watkins BA 2, Ajay Nangia M.B.B.S. 3, Richard Jacob Fantus MD 3, Courtney A. Marsh M.D., M.P.H 3
doi : 10.1016/j.fertnstert.2024.07.274
Volume 122, Issue 4, Supplement, October 2024, Pages e74-e75
Significant gaps in access to fertility care are widespread among racial minorities. Access to third party reproductive options, including use of donor sperm, is important for conceiving in the presence of male factor infertility and in the LGBTQ population. The national shortage of diverse sperm options exacerbates health inequities in reproduction. As of March 5, 2024 only 5.9% (75/1,277) of sperm in largest sperm banks were from Black donors. As 13.6% of the US population are Black (United States Census Quick Facts, 2023), this is a more than two-fold discrepancy in representation in the sperm donor pool. Our objective is to reduce health disparity in reproduction by advancing understanding of attitudes toward sperm donation in Black community
UNDERSTANDING PREGNANT AND EXPECTING DONOR GAMETE AND EMBRYO RECIPIENTS’ AND CLINICIANS’ PERCEPTIONS ABOUT COMPONENTS FOR EXPANDING THE TELL TOOL FOR USE DURING PREGNANCY
Patricia E. Hershberger PhD, RN, FNP-BC, FAAN 1, Kirby Adlam PhD, APRN-FPA, CNM 2, Ruchi Bhagat PhD 1, Valerie Gruss PhD, APRN, CNP-BC, FAAN 3, Martha Driessnack PhD, RN, PNP 4, Harold D. Grotevant PhD 5, Susan C. Klock PhD 6, Lauri Pasch PhD 7, Chelsea Fortin MD 8, Agatha M. Gallo PhD, RN, FAAN 2
doi : 10.1016/j.fertnstert.2024.07.275
Volume 122, Issue 4, Supplement, October 2024, Page e75
In its current state, the Tool to Empower Parental Telling and Talking (TELL Tool) is an evidence-based tool that is designed to provide decision and psychoeducational support to boost donor recipient parents’ confidence about talking with and telling their children, 1 to 16 years, about their genetic origins. The aim of this study was to obtain donor recipient individuals’, couples’ and clinicians’ perspectives about the components needed to expand the existing TELL Tool for use during pregnancy or the expecting period.
RANDOMIZED CONTROLLED TRIAL OF COMBINED LETROZOLE AND CLOMIPHENE (CLC II) VERSUS LETROZOLE MONOTHERAPY FOR WOMEN WITH ANOVULATION
Rachel B. Mejia D.O. 1, Karen M. Summers MPH CHES 2, Jessica Kresowik B.A., M.D. 3, Laura G. Cooney M.D. 4, Abigail C. Mancuso B.A., M.D. 1, Emily A. Capper M.D. 1, Bala Bhagavath M.B.B.S. 5, Bradley J. Van Voorhis M.D. 1
doi : 10.1016/j.fertnstert.2024.07.276
Volume 122, Issue 4, Supplement, October 2024, Page e75
To evaluate whether a combination of letrozole and clomiphene citrate results in higher ovulation rate than letrozole alone over three treatment cycles in women with infertility related to anovulation.
ALTERED ENDOMETRIAL CELL PROGESTERONE RESPONSIVENESS IN THE ETIOLOGY OF ENDOMETRIOSIS
Kathryn D. Coyne M.D. 1, Chloe Heather Van Dorn MPH 1, Sung Tae Kim PhD, HCLD 2, Joseph Findley M.D. 3, Rebecca Flyckt M.D. 2, Sam Mesiano PhD 4, Rachel Susan Weinerman M.D. 2
doi : 10.1016/j.fertnstert.2024.07.277
Volume 122, Issue 4, Supplement, October 2024, Page e76
To compare the abundance and function of progesterone receptor (PR) isoforms between endometrium in patients with and without endometriosis, and between endometrium and ectopic endometrial lesions in patients with endometriosis
PATTERNS OF UTILIZATION OF ADVANCED PRACTICE PROVIDERS IN REPRODUCTIVE ENDOCRINOLOGY: A 2023 NATIONAL SURVEY
Tamara Tobias N.P. 1, Nicole K. Callahan M.S., N.P. 2, Laura Augustine DNP, FNP-C 3, Barbara Tanaka MSN, WHNP-BC 4
doi : 10.1016/j.fertnstert.2024.07.279
Volume 122, Issue 4, Supplement, October 2024, Page e76
It has been proposed that by leveraging the skills and expertise of Advanced Practice Providers (APPs), fertility centers can help alleviate the shortage of fellowship-trained reproductive endocrinologists and improve access to care for patients seeking fertility treatments and reproductive health services. This study provides a current appraisal of Advanced Practice Provider demographics, training, and utilization within the field of reproductive endocrinology and infertility
IMPROVING FROZEN EMBRYO TRANSFER CONSENT TIMELY RETURN RATE TO REDUCE ADVERSE EVENTS AND IMPROVE PATIENT AND PROVIDER SATISFACTION
Jamie Feingold MSN, NP-C, WHNP-BC 1, Erin L. Scott M.D., PH.D., H.C.L.D. 2, Wendy S. Vitek M.D. 3, Kriston Ward B.S.N., M.S.N. 4, Alicia Collins B.S.N., R.N. 5
doi : 10.1016/j.fertnstert.2024.07.280
Volume 122, Issue 4, Supplement, October 2024, Pages e76-e77
Frozen embryo transfer (FET) consents require the signatures of two parties (patient and partner) that are notarized or witnessed by a clinic team member. The complexity of consenting 2 parties on paper with a witness prior to the start of a menstrual cycle-dependent procedure such as a FET combined with limitations of Epic electronic medicare record system led to over 25% of patients having missing and/or incomplete consents or orders at the start of FETs during a 2-month audit. The objective of this project was to decrease the number of patients who have missing orders and/or consents on the day of embryo transfer to >5% and eliminate major adverse events
IDENTIFYING THE GENETIC ETIOLOGY OF INFERTILITY AND RECURRENT PREGNANCY LOSS THROUGH A LARGE-SCALE WHOLE GENOME SEQUENCING DATASET
Roni Zemet MD 1, Erik Stricker PhD 1, Elizabeth Atkinson PhD 2, Ignatia B. Van Den Veyver MD 1
doi : 10.1016/j.fertnstert.2024.07.282
Volume 122, Issue 4, Supplement, October 2024, Page e77
Identify novel maternal genes associated with infertility and recurrent pregnancy loss (RPL) through a comprehensive analysis of large-scale genome sequencing data from the All of Us Research Program
DISCREPANCIES IN INFORMATION PROVIDED BY PROSPECTIVE OVUM DONORS IN THEIR APPLICATION COMPARED TO CONSULTATION WITH CERTIFIED GENETIC COUNSELOR AS PART OF ROUTINE SCREENING IN LARGE FERTILITY NETWORK
Lauri D. Black MS 1, Camelia V. Varriale BS 1, Emily Daugherty MS 2, Jacqueline Pierre-Louis MSc., (L)CGC, CCGC 2, Katie Caesar MS, LCGC 2, Daragh Castaneda B.A. 3
doi : 10.1016/j.fertnstert.2024.07.283
Volume 122, Issue 4, Supplement, October 2024, Pages e77-e78
To compare information obtained by written application to genetic risk assessment (GRA) by certified genetic counselors (CGC) for ovum donor applicants, and to assess the impact on eligibility based on ASRM and internal organization guidelines.
IMPACT OF STATE INSURANCE MANDATES ON IN VITRO FERTILIZATION UTILIZATION AMONG PATIENTS WITH RECURRENT PREGNANCY LOSS
Meridith Pollie MD 1, Benjamin J. Peipert MD 2, Tarun Jain M.D. 3, Marissa Steinberg Weiss M.D., M.SC. 4
doi : 10.1016/j.fertnstert.2024.07.284
Volume 122, Issue 4, Supplement, October 2024, Page e78
To evaluate if state in vitro fertilization (IVF) insurance mandates with language inclusive of patients with recurrent pregnancy loss (RPL) were associated with increased utilization of IVF for this indication in 2021.
DO STATE INSURANCE MANDATES PROTECT FERTILITY PATIENTS?
Adeola Adeyeye MD 1, Katherine Koniares M.D. 2, Eliana Fine MD 3, James R. Stelling M.D. 4
doi : 10.1016/j.fertnstert.2024.07.285
Volume 122, Issue 4, Supplement, October 2024, Page e78
To examine how, and if, state insurance mandates for fertility insurance coverage include protection against discrimination in the setting of assisted reproductive technology.
THE PREVALENCE OF POST-TRAUMATIC STRESS DISORDER SYMPTOMS IN INDIVIDUALS PRESENTING FOR FERTILITY CARE: A CROSS-SECTIONAL STUDY
Sam JF. Melville MD 1, Teni Davoudian PH.D. 2, Sacha A. Krieg M.D., PH.D. 2, Elizabeth S. Rubin M.D. 2
doi : 10.1016/j.fertnstert.2024.07.287
Volume 122, Issue 4, Supplement, October 2024, Page e79
To investigate the prevalence of Post-Traumatic Stress Disorder (PTSD) symptoms in patients presenting for fertility care and compare rates in those with recurrent pregnancy loss (RPL) to those without RPL
THE IMPACT OF PCOS ON THE RURAL INDIAN SUBFERTILE POPULATION WITH RESPECT TO EMOTIONAL & MENTAL WELL-BEING; AN OBSERVATIONAL STUDY
Seema Tripathi Pandey MBBS, MD 1, Kamal Ojha M.D., FRCOG 2, Kanishk Khanduri B. pharm 3, Diksha Singh MSc in Clinical Psychology 4
doi : 10.1016/j.fertnstert.2024.07.288
Volume 122, Issue 4, Supplement, October 2024, Page e79
To explore the emotional & mental wellbeing including body image concerns in women and individuals with PCOS
RECOGNIZING AND IMPROVING TRAUMA INFORMED CARE IN THE FERTILITY CLINIC SETTING
Jeanine Price DNP, MSN
doi : 10.1016/j.fertnstert.2024.07.289
Volume 122, Issue 4, Supplement, October 2024, Pages e79-e80
Trauma-informed care (TIC) is defined as a patient-centered concept of care that incorporates the recognition of a patient's history and the use of appropriate clinical skills to avoid revictimization. An estimated 23 million women report that they have been a victim of rape or sexual trauma during their lifetime. Care for this patient population requires the use of specific clinical strategies that promote the use of TIC. Failure to recognize the need for TIC, has a broad social impact which contributes to adverse health outcomes, including infertility and pregnancy. The aim of this quality improvement (QI) project was to determine if a TIC educational bundle improved recognition of the patient history of trauma, improved reporting of the history of trauma into the electronic medical record, and increased referrals to mental healthcare professionals
RELATING TO THE PREVALENCE OF DEPRESSION SYMPTOMS IN INFERTILE WOMEN AND SOCIAL, PSYCHOLOGICALÂ CHARACTERISTICS
Min Kyung Kwon
doi : 10.1016/j.fertnstert.2024.07.290
Volume 122, Issue 4, Supplement, October 2024, Page e80
Identify the demographic-sociological characteristics, the infertility characteristics, the social?psychological characteristics, the degree of depression prevalence of infertile women and the characteristics of those who are related to depression prevalence. Based on the results, the purpose is to develop programs for psychological support and treatment and to provide basic data for improving the quality of infertility medicalservices
PREVENTING TRANSMISSION OF AN ENDOMETRIOSIS-LIKE PHENOTYPE AND RISK OF PRETERM BIRTH IN ADULT DAUGHTERS OF DIOXIN EXPOSED MALE MICE
Kaylon Bruner-Tran PH.D. 1, Isabella R. Land NA 2, Kevin Osteen PH.D. 2
doi : 10.1016/j.fertnstert.2024.07.292
Volume 122, Issue 4, Supplement, October 2024, Page e80
Women with endometriosis exhibit a reduced ability to respond to progesterone (P4) due to hypermethylation of the P4 receptor gene. P4 action is critical to healthy pregnancy; thus, it is not surprising endometriosis has been linked to subfertility and preterm birth (PTB). Women with endometriosis also exhibit a loss of uterine expression of the tumor suppressor gene ARID1A which may contribute to an increased risk of cancer. While viewed as a woman’s disease, our studies indicate paternal-derived factors can affect a daughter’s risk of reproductive dysfunction. Specifically, using a mouse model, we have demonstrated a history of paternal exposure to the environmental toxicant dioxin was associated with the development of an endometriosis-like uterine phenotype in adult female offspring. Herein, we examined the efficacy of preconception fish oil therapy to prevent development of reproductive dysfunction in adult females following a paternal exposure.
ELECTROPHYSIOLOGICAL IMAGING IDENTIFIES DISRUPTED UTERINE PERISTALSIS IN WOMEN WITH ENDOMETRIOSIS
Sicheng Wang PhD 1, Courtney Murphy M.D. 2, Valerie Ratts M.D. 3, Yong Wang PhD 1
doi : 10.1016/j.fertnstert.2024.07.293
Volume 122, Issue 4, Supplement, October 2024, Pages e80-e81
To utilize a noninvasive electrophysiology imaging system called Uterine Peristalsis Imaging (UPI) to measure and quantify the electrical activity associated with uterine peristalsis throughout the menstrual cycle in both healthy individuals and those with endometriosis.
PREVALENCE OF SOMATIC CANCER DRIVER MUTATIONS IN EPITHELIAL CELLS IN CASES OF EXTREME ENDOMETRIOSIS COMPARED TO SUPERFICIAL ENDOMETRIOSIS
Elizabeth Schlant BA, BS 1, Bhuchitra Singh MD, MPH, MS, MBA 2, James H. Segars MD, FACOG 2, Maria Antero MD 3, Lucy Xi Chen M.D. 4
doi : 10.1016/j.fertnstert.2024.07.294
Volume 122, Issue 4, Supplement, October 2024, Page e81
To identify the types of somatic cancer driver mutations in cases of extreme endometriosis compared to superficial endometriosis using laser capture microdissection and whole exome sequencing
ABERRANT MAPK3/1 AND AKT SIGNALING PATHWAYS IN GRANULOSA CELLS MAY CONTRIBUTE TO THE COMPROMISED FOLLICULAR DEVELOPMENT OF THE ENDOMETRIOSIS PATIENTS
Gentry K. Cork MS, Asrafun Nahar PH.D., William B. Schoolcraft M.D., Ye Yuan PhD
doi : 10.1016/j.fertnstert.2024.07.295
Volume 122, Issue 4, Supplement, October 2024, Page e81
Endometriosis is a gynecological disorder characterized by endometrium tissue growth outside of the uterus and has been reported to alter follicle metabolism, lower egg retrieval yield, and compromise oocyte quality. Our previous study confirmed impaired mitochondrial function and cell proliferation in granulosa cells that may be correlated with the diminished oocyte quality in endometriosis patients. The purpose of this study was to examine the mechanisms that may explain this phenotype
GENOTYPE-PHENOTYPE ASSOCIATIONS IN ENDOMETRIOSIS AND ADENOMYOSIS: USING WHOLE-EXOME SEQUENCING TO CHARACTERIZE GENETIC BURDEN IN CANDIDATE GENES ASSOCIATED WITH ENDOMETRIOSIS
Leigh A. Humphries MD 1, Lindsay A. Guare BS 2, Margaret A. Rush MD 1, Meridith Pollie MD 1, Shefali Setia Verma PhD 2, Suneeta Senapati MD, MSCE 2
doi : 10.1016/j.fertnstert.2024.07.296
Volume 122, Issue 4, Supplement, October 2024, Page e82
Genetic predisposition is a key risk factor for endometriosis, with an estimated heritability of up to 50%. Genome-wide association studies (GWAS) have identified 42 novel genomic loci, or single-nucleotide polymorphisms (SNPs) in the noncoding genome, associated with endometriosis. It is hypothesized that genes adjacent to SNPs may play roles in disease pathogenesis. Building on prior GWAS findings, our study utilized an exome-wide association study (ExWAS) approach to measure the extent of loss-of-function mutations in the coding regions of candidate genes and elucidate their associations with endometriosis and adenomyosis
DISPROPORTIONALITY ANALYSIS WITH COMPARISON OF ELAGOLIX VERSUS LEUPROLIDE SAFETY IN WOMEN WITH ENDOMETRIOSIS USING DATA FROM THE FDA ADVERSE EVENT REPORTING SYSTEM (FAERS)
Megan E. Gornet M.D. 1, Bronwyn S. Bedrick MD, MSCI 2, Katherine E. Cameron M.D. 3
doi : 10.1016/j.fertnstert.2024.07.297
Volume 122, Issue 4, Supplement, October 2024, Pages e82-e83
Elagolix (Egx) was approved by the Food and Drug Administration (FDA) in July 2018 for the management of endometriosis, whereas leuprolide (Lupron) has been standard of care. To gain insight into adverse events (AEs) associated with the nouveau Egx continued surveillance of safety data is critical. Our objective was to review Egx- and Lupron-associated AEs in women treated for endometriosis using the FDA adverse event reporting system (FAERS)
