American Journal of Transplantation




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American Journal of Transplantation: Volume 22, Number 3, March 2022

doi : 10.1111/ajt.16650

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Stem cell–derived islets take a leap toward patients

Lara C. Pullen PHD

doi : 10.1111/ajt.16647

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NK cells are caught in human kidney allograft rejection

Xian C. Li MD, PHD

doi : 10.1111/ajt.16648

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Revisiting acute T cell–mediated rejection in kidney allografts

Ilkka Helanterä, Michael Mengel

doi : 10.1111/ajt.16923

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T cell–mediated rejection in kidney transplant recipients: The end(point) is also the beginning

Sindhu Chandran, Roslyn B. Mannon

doi : 10.1111/ajt.16964

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Transplant oncology in locally advanced intrahepatic cholangiocarcinoma: One more step on a long road

Tommy Ivanics, Christian Toso, Sumera I. Ilyas, Gonzalo Sapisochin

doi : 10.1111/ajt.16944

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Getting more hearts into more kids: Can we do it?

William T. Mahle, Steven A. Webber

doi : 10.1111/ajt.16939

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Is downregulation of liver kinase B1 the major factor driving epithelial-to-mesenchymal transition?

Saskia Bos, Andrew J. Fisher

doi : 10.1111/ajt.16941

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Imlifidase for the treatment of anti-HLA antibody-mediated processes in kidney transplantation

Edmund Huang, Angela Q. Maldonado, Christian Kjellman, Stanley C. Jordan

doi : 10.1111/ajt.16828

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Human leukocyte antigen antibody sensitization, lung transplantation, and health equity

Andrew M. Courtwright, Namrata Patel, Anil Chandraker, Hilary J. Goldberg

doi : 10.1111/ajt.16795

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Novel intragraft regulatory lymphoid structures in kidney allograft tolerance

Ivy A. Rosales, Chao Yang, Evan A. Farkash, Tameem Ashry, Jifu Ge, Imad Aljabban, Archana Ayyar, Dorothy Ndishabandi, Rebecca White, Elena Gildner, Jingjing Gong, Yan Liang, Fadi G. Lakkis, Volker Nickeleit, Paul S. Russell, Joren C. Madsen, Alessandro Alessandrini, Robert B. Colvin

doi : 10.1111/ajt.16880

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Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair

Kelly Walton, Kirsti Walker, Megan Riddle, Brent H. Koehn, Jordan Reff, Elizabeth M. Sagatys, Michael A. Linden, Joseph Pidala, Jongphil Kim, Marie C. Lee, John V. Kiluk, Jane Yuet Ching Hui, Sang Y. Yun, Yan Xing, Heather Stefanski, Harshani R. Lawrence, Nicholas J. Lawrence, Jakub Tolar, Claudio Anasetti, Bruce R. Blazar, Said M. Sebti, Brian C. Betts

doi : 10.1111/ajt.16870

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Transplantation of bioengineered liver capable of extended function in a preclinical liver failure model

Hisanobu Higashi, Hiroshi Yagi, Kohei Kuroda, Kazuki Tajima, Hideaki Kojima, Kotaro Nishi, Toshinori Morisaku, Kazuya Hirukawa, Kazumasa Fukuda, Kentaro Matsubara, Minoru Kitago, Masahiro Shinoda, Hideaki Obara, Shungo Adachi, Kumiko Nishimura, Tohru Natsume, Masatoshi Tomi, Alejandro Soto-Gutierrez, Yuko Kitagawa

doi : 10.1111/ajt.16928

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Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques

Melanie L. Graham, Sabarinathan Ramachandran, Amar Singh, Meghan E. G. Moore, E. Brian Flanagan, Agnes Azimzadeh, Christopher Burlak, Kate R. Mueller, Kyra Martins, Takayuki Anazawa, Balamurugan N. Appakalai, Pratima Bansal-Pakala, Michael P. Murtaugh, Timothy D. O'Brien, Klearchos K. Papas, Thomas Spizzo, Henk-J. Schuurman, Wayne W. Hancock, Bernhard. J. Hering

doi : 10.1111/ajt.16876

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The negative impact of T cell–mediated rejection on renal allograft survival in the modern era

Christie Rampersad, Robert Balshaw, Ian W. Gibson, Julie Ho, Jamie Shaw, Martin Karpinski, Aviva Goldberg, Patricia Birk, David N. Rush, Peter W. Nickerson, Chris Wiebe

doi : 10.1111/ajt.16883

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Effectiveness of T cell–mediated rejection therapy: A systematic review and meta-analysis

Julie Ho, George N. Okoli, Rasheda Rabbani, Otto L. T. Lam, Viraj K. Reddy, Nicole Askin, Christie Rampersad, Aaron Trachtenberg, Chris Wiebe, Peter Nickerson, Ahmed M. Abou-Setta

doi : 10.1111/ajt.16907

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Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring

Marta Crespo, Antoni Barrilado-Jackson, Eduardo Padilla, Jorge Eguía, Daniel Echeverria-Esnal, Higini Cao, Anna Faura, Montserrat Folgueiras, Eulàlia Solà-Porta, Sergi Pascual, Francesc Barbosa, Sara Hurtado, Laura Ribera, Laura Río-No, María José Pérez-Sáez, Dolores Redondo-Pachón, Julio Pascual

doi : 10.1111/ajt.16854

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Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic

Tomas Reischig, Martin Kacer, Tomas Vlas, Petr Drenko, Lukas Kielberger, Jana Machova, Ondrej Topolcan, Radek Kucera, Stanislav Kormunda

doi : 10.1111/ajt.16902

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SARS-CoV-2-specific humoral and cell-mediated immune responses after immunization with inactivated COVID-19 vaccine in kidney transplant recipients (CVIM 1 study)

Jackrapong Bruminhent, Chavachol Setthaudom, Pongsathon Chaumdee, Sarinya Boongird, Sasisopin Kiertiburanakul, Kumthorn Malathum, Arkom Nongnuch, Angsana Phuphuakrat, Sopon Jirasiritham, Chitimaporn Janphram, Sansanee Thotsiri, Supparat Upama, Montira Assanatham, The Ramathibodi Transplant Infectious Diseases (RTID) Study Group

doi : 10.1111/ajt.16867

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Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma

Robert R. McMillan, Milind Javle, Sudha Kodali, Ashish Saharia, Constance Mobley, Kirk Heyne, Mark J. Hobeika, Keri E. Lunsford, David W. Victor III, Akshay Shetty, Robert S. McFadden, Maen Abdelrahim, Ahmed Kaseb, Mukul Divatia, Nam Yu, Joy Nolte Fong, Linda W. Moore, Duc T. Nguyen, Edward A. Graviss, A. Osama Gaber, Jean-Nicolas Vauthey, R. Mark Ghobrial

doi : 10.1111/ajt.16906

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Pediatric heart transplant waiting times in the United States since the 2016 allocation policy change

Ryan J. Williams, Minmin Lu, Lynn A. Sleeper, Elizabeth D. Blume, Paul Esteso, Francis Fynn-Thompson, Christina J. Vanderpluym, Simone Urbach, Kevin P. Daly

doi : 10.1111/ajt.16921

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Novel role for tumor suppressor gene, liver kinase B1, in epithelial–mesenchymal transition leading to chronic lung allograft dysfunction

Mohammad Rahman, Ranjithkumar Ravichandran, Sandhya Bansal, Kristina Sanborn, Sara Bowen, Jennifer Eschbacher, Angara Sureshbabu, Timothy Fleming, Ankit Bharat, Rajat Walia, Ramsey Hachem, Ross M. Bremner, Michael A. Smith, Thalachallour Mohanakumar

doi : 10.1111/ajt.16903

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HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

Christine M. Durand, Sander Florman, Jennifer D. Motter, Diane Brown, Darin Ostrander, Sile Yu, Tao Liang, William A. Werbel, Andrew Cameron, Shane Ottmann, James P. Hamilton, Andrew D. Redd, Mary G. Bowring, Yolanda Eby, Reinaldo E. Fernandez, Brianna Doby, Nazzarena Labo, Denise Whitby, Wendell Miley, Rachel Friedman-Moraco, Nicole Turgeon, Jennifer C. Price, Peter Chin-Hong, Peter Stock, Valentina Stosor, Varvara A. Kirchner, Timothy Pruett, David Wojciechowski, Nahel Elias, Cameron Wolfe, Thomas C. Quinn, Jonah Odim, Megan Morsheimer, Sapna A. Mehta, Meenakshi M. Rana, Shirish Huprikar, Allan Massie, Aaron A. R. Tobian, Dorry L. Segev, the HOPE in Action Investigators

doi : 10.1111/ajt.16886

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IgG3 donor–specific antibodies with a proinflammatory glycosylation profile may be associated with the risk of antibody-mediated rejection after kidney transplantation

Vincent Pernin, Nicole Bec, Anaïs Beyze, Alexis Bourgeois, Ilan Szwarc, Coralie Champion, Anthony Chauvin, Céline Rene, Georges Mourad, Pierre Merville, Jonathan Visentin, Helene Perrochia, Lionel Couzi, Christian Larroque, Moglie Le Quintrec

doi : 10.1111/ajt.16904

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Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney

Priyanka Rashmi, Swastika Sur, Tara K. Sigdel, Patrick Boada, Andrew W. Schroeder, Izabella Damm, Matthias Kretzler, Jeff Hodgin, George Hartoularos, Chun Jimmie Ye, Minnie M. Sarwal, For The Kidney Precision Medicine Project

doi : 10.1111/ajt.16871

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Healthcare professional and community preferences in deceased donor kidney allocation: A best-worst scaling survey

Matthew P. Sypek, Martin Howell, Kirsten Howard, Germaine Wong, Emily Duncanson, Philip D. Clayton, Peter Hughes, Stephen McDonald

doi : 10.1111/ajt.16898

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Trends in the procurement and discard of kidneys from deceased donors with acute kidney injury

Caroline Liu, Sami Alasfar, Peter P. Reese, Sumit Mohan, Mona D. Doshi, Isaac E. Hall, Heather Thiessen Philbrook, Yaqi Jia, Darren Stewart, Chirag R. Parikh

doi : 10.1111/ajt.16920

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The molecular phenotypes of injury, steatohepatitis, and fibrosis in liver transplant biopsies in the INTERLIVER study

Katelynn S. Madill-Thomsen, Marwan Abouljoud, Chandra Bhati, Michał Ciszek, Magdalena Durlik, Sandy Feng, Bartosz Foroncewicz, Iman Francis, Michał Grąt, Krzysztof Jurczyk, Goran Klintmalm, Maciej Krasnodębski, Geoff McCaughan, Rosa Miquel, Aldo Montano-Loza, Dilip Moonka, Krzysztof Mucha, Marek Myślak, Leszek Pączek, Agnieszka Perkowska-Ptasińska, Grzegorz Piecha, Trevor Reichman, Alberto Sanchez-Fueyo, Olga Tronina, Marta Wawrzynowicz-Syczewska, Andrzej Więcek, Krzysztof Zieniewicz, Philip F. Halloran

doi : 10.1111/ajt.16890

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Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients

Freya Van Hulle, Kaat De Groot, Robert Hilbrands, Ursule Van de Velde, Krista Suenens, Geert Stangé, Ines De Mesmaeker, Diedert L. De Paep, Zhidong Ling, Bart Roep, Pieter Gillard, Daniel Pipeleers, Bart Keymeulen, Daniel Jacobs-Tulleneers-Thevissen

doi : 10.1111/ajt.16884

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Posttraumatic stress and medication adherence in pediatric transplant recipients

Sarah Duncan-Park, Lara Danziger-Isakov, Brian Armstrong, Nikki Williams, Jonah Odim, Eyal Shemesh, Stuart Sweet, Rachel Annunziato

doi : 10.1111/ajt.16896

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Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells

Timna Agur, Johannes Wedel, Sayantan Bose, A. G. Pramoda Sahankumari, Daniel Goodman, Sek Won Kong, Chandra C. Ghosh, David M. Briscoe

doi : 10.1111/ajt.16872

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Blockade or deficiency of PD-L1 expression in intestinal allograft accelerates graft tissue injury in mice

Hajime Matsushima, Miwa Morita-Nakagawa, Shyamasree Datta, Paul G. Pavicic Jr, Thomas A. Hamilton, Kareem Abu-Elmagd, Masato Fujiki, Mohammed Osman, Giuseppe D’Amico, Susumu Eguchi, Koji Hashimoto

doi : 10.1111/ajt.16873

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Intrapleural transplantation of allogeneic pancreatic islets achieves glycemic control in a diabetic non-human primate

Ji Lei, Alexander Zhang, Hongping Deng, Zhihong Yang, Cole W. Peters, Kang M. Lee, Zhenjuan Wang, Ivy A. Rosales, Charles G. Rickert, James F. Markmann

doi : 10.1111/ajt.16875

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High levels of donor-derived cell-free DNA in a case of graft-versus-host-disease following liver transplantation

Duncan Lewis, Renata Glehn-Ponsirenas, Natali Gulbahce, Leah J. Hooey, Joanna M. Chaffin, Jake Miles, Robert Woodward, Sergio Duarte, Thiago Beduschi, Ali Zarrinpar

doi : 10.1111/ajt.16894

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Alloantibodies after simultaneous liver-kidney transplant: A story of primary nonfunction, retransplantation, and antibody-mediated rejection

Daniel S. Ramon, Danielle M. Troop, Theresa N. Kinard, Caroline C. Jadlowiec, Margaret S. Ryan, Winston R. Hewitt Jr, Linda G. Olsen, Andrés Jaramillo, Timucin Taner, Raymond L. Heilman

doi : 10.1111/ajt.16913

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Use of recombinant zoster vaccine in immunocompromised adults aged ≥19 years: Recommendations of the Advisory Committee on Immunization Practices—United States, 2022

Tara C. Anderson, Nina B. Masters, Angela Guo, Leah Shepersky, Andrew J. Leidner, Grace M. Lee, Camille N. Kotton, Kathleen L. Dooling

doi : 10.1111/ajt.16649

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Cardiac graft loss in transplant recipient with Chagas disease

Monica Samuel Avila, Deborah de Sá Pereira Belfort, Victor de Vicente Leite, Léa Maria Macruz Ferreira Demarche, Silvia Moreira Ayub-Ferreira

doi : 10.1111/ajt.16919

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Hybrid immunity to SARS-CoV-2 in kidney transplant recipients and hemodialysis patients

Delphine Kemlin, Anne Lemy, Pieter Pannus, Isabelle Desombere, Nicolas Gemander, Maria E. Goossens, Arnaud Marchant, Alain Le Moine

doi : 10.1111/ajt.16853

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Liver graft outcomes from donors with vaccine induced thrombosis and thrombocytopenia (VITT): United Kingdom multicenter experience

Angus Hann, Hermien Hartog, Anisa Nutu, Katherine Quist, Rebecca Sanabria-Mateos, George H. B. Greenhall, Ines Ushiro-Lumb, Phillip L. R. Nicolson, Owen Cain, Ye H. Oo, Abhishek Chauhan, Will Lester, Joerg-Matthias Pollok, Andreas Prachalias, John R. Isaac, Douglas Thorburn, John Forsythe, Khalid Sharif, Desley A. H. Neil, Darius F. Mirza, M. Thamara P. R. Perera

doi : 10.1111/ajt.16869

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The first international roundtable on “organ donation after circulatory death by medical assistance in dying� demonstrates increasing incidence of successful patient-driven procedure

Johannes Mulder, Hans Sonneveld, Andrew Healey, Dirk Van Raemdonck

doi : 10.1111/ajt.16879

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18-Fluorodeoxyglucose positron emission computed tomography for systemic oxalosis in primary hyperoxaluria type 1

Arnaud Devresse, Renaud Lhommel, Nathalie Godefroid, Eric Goffin, Nada Kanaan

doi : 10.1111/ajt.16887

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